Agent Name

Methylenediphenyl diisocyanate

Alternative Name

MDI

CAS Number

26447-40-5

Formula

C15-H10-N2-O2

Major Category

Plastics & Rubber

Synonyms

4,4'-,2,4'-,2,2'-Diisocyanatodiphenylmethane; Diphenylmethane diisocyanate; Isocyanic acid, methylenediphenylene ester; Benzene, 1,1'-methylenebis(isocyanato-; Crude MDI; Generic MDI; Non-isomeric-specific MDI; [ChemIDplus] 1,1'-Methylenebis(isocyanatobenzene); 2,4'/4,4'-Diphenylmethandiisocyanat; Difenilmetanodiisocianato; Diphenylmetha-4,4'-diisocyanat; Diphenylmethane-4,4'-diisocyanate and isomers; Diphenylmethane-4,4'-diisocyanate; Isocyanic acid, methylenediphenylene ester; MDI; MDI-Gemisch; Methyldiphenyldiisocyanat; [IUCLID] Methylenebis (phenyl isocyanate); [ToxPlanet: Official Journal of the European Union] MONDUR ML; [Bayer Material Science MSDS] UN3082

Category

Diisocyanates

Description

Polymeric MDI: Dark amber viscous liquid; Pure 4,4'-MDI: White waxy solid; [ToxPlanet: CPS&Q: RARs - Final Report] Light to dark yellow liquid with a mild musty odor; mp = 15-20 deg C; [Bayer Material Science MSDS]

Sources/Uses

Used in the furniture, car, shoe, carpet, refrigerators and freezers, textile, coatings, and construction industries; [IUCLID] Used primarily in the manufacture of rigid polyurethane foams; Other uses include coatings, adhesives, sealants, elastomers, paints, footwear, (semi) flexible and thermoplastic polyurethane foams, polyurethane fibers, and to make particle board and foundry mould cores; [ToxPlanet: CPS&Q: RARs - Final Report]

Comments

This CAS refers not only to isomeric mixtures but also all the specific isomers including those with unique CAS numbers; A skin, eye, and respiratory tract irritant; Allergic contact dermatitis, contact urticaria, asthma, and hypersensitivity pneumonitis reported from occupational exposure; Long term occupational inhalation exposure has demonstrated decreased ventilatory function and respiratory symptoms even at levels below current guidelines; [ToxPlanet: CPS&Q: RARs - Final Report] Causes contact urticaria; [Kanerva, p. 219] Reacts slowly with water evolving carbon dioxide; An irritant; May cause skin and respiratory sensitization; Inhalation overexposure may cause bronchitis, bronchial spasm, and pulmonary edema; [Bayer Material Science MSDS] See "Methylene bisphenyl isocyanate."

Reference Link

INCHEM CICADs: Diphenylmethane diisocyanate (MDI) - 2000

Exposure Assessment
Vapor Pressure

4.0E-6 mm Hg

Odor Threshold Low

0.4 ppm

RD50

3 ppm

Lethal Concentration

LC50 (rat) = 369 mg/m3/4hr

Explanatory Notes

Odor threshold from IUCLID; The Guide in the Emergency Response Guidebook is for "Other regulated substances, liquid, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Toxic Pneumonitis

Yes

Fibrogenic

Yes

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: