Agent Name

Methyl cellosolve acetate

Alternative Name

EGMEA

CAS Number

110-49-6

Formula

C5-H10-O3

Major Category

Solvents

Synonyms

2-Methoxy-ethyl acetaat [Dutch]; 2-Methoxyaethylacetat [German]; 2-Methoxyethanol, acetate; 2-Methoxyethyl acetate; 2-Methoxyethyle, acetate de [French]; 2-Methoxyethylester kyseliny octove [Czech]; 2-Methyoxyethylacetate; 2-Metossietilacetato [Italian];Acetate de l'ether monomethylique de l'ethylene-glycol; [French]; Acetate de methyle glycol [French]; Acetato di metil cellosolve [Italian]; Acetic acid 2-methoxyethyl ester; Acetyl methyl cellosolve; Aethylenglykolmethylaetheracetat [German]; EGMEA; Ethanol, 2-methoxy-, acetate; Ethylene glycol acetate monomethyl ether; Ethylene glycol methyl ether acetate; Ethylene glycol monomethyl ether acetate; Ethylene glycol monomethyl ether monoacetate; Glycol monomethyl ether acetate; MeCsac; Methyl Cellosolve acetate; Methyl cellosolye acetaat [Dutch]; Methyl glycol acetate; Methyl glycol monoacetate; Methylcellosolveacetate; Methylcelosolvacetat [Czech]; Methylglycolacetate; Methylglykolacetat [German]; beta-Methoxyethyl acetate; [ChemIDplus] UN1189

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a pleasant odor; [CAMEO]

Sources/Uses

Used as a solvent and in the production of photographic films and textile printing; [ACGIH]

Comments

After repeated 8-hour exposures to 200-1000 ppm, animals show evidence of kidney and bone marrow damage. [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Potential adverse effects include injury to the bone marrow, kidneys, and CNS (unconsciousness). May be a reproductive toxin and defat the skin; [ICSC] See "Glycol ethers."

Restricted

The Semiconductor Industry Association recommends elimination of this solvent because of potential reproductive effects. [CHS, p. 43]

Exposure Assessment
BEI

2-Methoxyacetic acid in urine = 1 mg/g creatinine; end of shift at end of workweek; [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 ppm

PEL (OSHA)

25 ppm

MAK

1 ppm, sum of concentrations of CAS 109-86-4 and its acetate in air

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Human data: It has been stated that methyl Cellosolve acetate is slightly less toxic than methyl Cellosolve [Gosselin et al. 1984].

Vapor Pressure

2 mm Hg

Odor Threshold Low

0.33 ppm

Odor Threshold High

0.64 ppm

Lethal Concentration

LCLo (rat) = 7,000 ppm/4 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.33 ppm); Flash point = 111 deg F;

Reference Link

ICSC: Methoxyethyl acetate

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: