Agent Name


CAS Number




Major Category



2-Dimethoxyphosphinothioylthio-N-methylacetamide; 8014 Bis HC; AC-12880; AC-18682; Aadimethoal; Acetic acid, O,O-dimethyldithiophosphoryl-, N-monomethylamide salt; American cyanamid 12880; BI 58 EC; BI-58; CL 12880; Cekuthoate; Cygon; Cygon 2-E; Cygon 400; Cygon 4E; Cygon insecticide; Daphene; De-fend; Demos-L40; Devigon; Dimate 267; Dimetate; Dimethoaat; Dimethoaat [Dutch]; Dimethoat; Dimethoat Tech 95%; Dimethoat [German]; Dimethoate 30 EC; Dimethogen; Dimeton; Dimevur; Dithiophosphate de O,O-dimethyle et de S(-N-methylcarbamoyl-methyle) [French]; EI-12880; ENT 24,650; Experimental insecticide 12,880; FIP; Ferkethion; Fortion NM; Fosfamid (USSR); Fosfatox R; Fosfotox; Fosfotox R; Fosfotox R 35; Fostion MM; L-395; Lurgo; N-Monomethylamide of O,O-dimethyldithiophosphorylacetic acid; O,O-Dimethyl S-((methylcarbamoyl)methyl)phosphorodithioate; O,O-Dimethyl S-(2-(methylamino)-2-oxoethyl) phosphorodithioate; O,O-Dimethyl S-(N-methylcarbamoylmethyl) dithiophosphate; O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorodithioate; O,O-Dimethyl S-(N-methylcarbamylmethyl) thiothionophosphate; O,O-Dimethyl S-methylcarbamoylmethyl phosphorodithioate; O,O-Dimethyl methylcarbamoylmethyl phosphorodithioate; O,O-Dimethyl phosphorodithioate S-ester with 2-mercapto-N-methylacetamide (8CI); O,O-Dimethyl-S-(2-oxo-3-aza-butyl)-dithiophosphat [German]; O,O-Dimethyl-S-(N-methyl-carbamoyl)-methyl-dithiofosfaat [Dutch]; O,O-Dimethyl-S-(N-methyl-carbamoyl-methyl)-dithiophosphat [German]; O,O-Dimethyl-S-(N-monomethyl)-carbamyl methyl dithiophosphate; O,O-Dimethyl-dithiophosphorylessigsaeure monomethylamid [German]; O,O-Dimethyldithiophosphorylacetic acid, N-monomethylamide salt; O,O-Dimetil-S-(N-metil-carbamoil-metil)-ditiofosfato [Italian]; OMS 94; PEI 75; Perfecthion; Perfekthion; Phosphamid; Phosphamide; Phosphorodithioic acid O,O-dimethyl ester, ester with 2-mercapto-N-methylacetamide; Phosphorodithioic acid, O,O-dimethyl ester, S-ester with 2-mercapto-N-methylacetamide; Racusan; Rebelate; Rogodan; Rogor; Rogor 20L; Rogor 40; Rogor L; Rogor P; Roxion; Roxion UA; S-Methylcarbamoylmethyl O,O-dimethyl phosphorodithioate; Salut; Sevigor; Sinoratox; Sistemin; Solut; Systemin; Systoate; Tara; Tara 909; Trimetion; Phosphorodithioic acid, O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) ester; [ChemIDplus] UN2783


Organophosphate Insecticides


Solid; [Merck Index] Colorless when pure; [ICSC] Technical product is white to grayish; [CAMEO] White solid with an odor of mercaptans; Formulated as emulsifiable concentrate and wettable powder end-use-products; [Reference #2]


Used as systemic and contact insecticide; [Merck Index] A general use OP insecticide/acaricide used on various crops and ornamentals (mostly alfalfa, wheat, cotton, and corn); [Reference #2]


An erythema-multiforme-like contact dermatitis has been reported; [Kanerva, p. 1783] A cholinesterase inhibitor that can be absorbed through skin; May have adverse effects on human reproduction, based on animal studies; [ICSC] Has the highest reported incidence of poisonings (none life-threatening) of the Ops used in residential applications; No evidence of delayed neurotoxicity in hens; [Reference #2] Delayed neuropathy has been very rarely reported in humans, and seems to result from severe poisoning; Not likely to cause delayed neuropathy under normal levels of exposure; May cause an "intermediate syndrome" that can be life threatening; Symptoms developing 1-4 days following exposure include weakness of proximal limb muscles and neck flexors and respiratory distress; Four cases have been reported and involved ingestion of large amounts; [EFSA] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs] See "Omethoate."


Residential uses cancelled in the US in 2000; [Reference #2]

Reference Link

Erythema-multiforme-like contact dermatitis from dimethoate

Exposure Assessment

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

8.25E-6 mm Hg

Lethal Concentration

LC50 = 1,680 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, solid, toxic."

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Other Poison


Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

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Biomedical References

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Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: