| Agent Name | Quinidine |
|---|---|
| CAS Number | 56-54-2 |
| Formula | C20-H24-N2-O2 |
| Major Category | Biological Agents |
| Synonyms | (+)-Quinidine; (8R,9S)-Quinidine; (9S)-6'-Methoxycinchonan-9-ol; (9S)-6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol; Chinidin [German]; Cinchonan-9-ol, 6'-methoxy-, (9S)-; Conchinin; Conquinine; Pitayine; alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol (9S)-; beta-Quinine; [ChemIDplus] |
| Category | Plant Toxins |
| Description | Triboluminescent solid; [Merck Index] |
| Sources/Uses | Used as a human and veterinary antiarrhythmic and human antimalarial; [Merck Index] |
| Comments | "Quinidine sulfate has elicited contact allergy in production workers, and patch test with quinine were negative." [Kanerva, p. 435] Quinidine may induce photosensitivity in patients taking it systemically (photodrug reaction). [Marks, p. 201-3] As an oral medication, quinidine is used to treat heart arrhythmias. Many side effects have been reported after ingestion of therapeutic doses, including immune hemolytic anemia and drug-induced hepatitis. [HSDB] Therapeutic serum levels are 2-4 mg/L, and serious adverse effects are unusual in that range. A one gram dose is potentially lethal to adults. Toxic effects include ventricular tachycardia and depression of cardiac contractility. Other symptoms are vomiting, diarrhea, and anticholinergic effects. Seizures and coma may follow. Symptoms of chronic poisoning (cinchonism) are tinnitus, vertigo, deafness, and visual dsturbances. [Olson, p. 356-7] |
| Reference Link | The lymphocyte transformation test for diagnosis of drug-induced occupational allergy |
| Adverse Effects | |
| Skin Sensitizer | Yes |
| Hepatotoxin | Hepatotoxin, Secondary |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Biomedical References | |
| Related Information in HazMap | |
| Diseases | Occupational diseases associated with exposure to this agent: |
Agent Name
Quinidine
CAS Number
56-54-2
Formula
C20-H24-N2-O2
Major Category
Biological Agents
Synonyms
(+)-Quinidine; (8R,9S)-Quinidine; (9S)-6'-Methoxycinchonan-9-ol; (9S)-6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol; Chinidin [German]; Cinchonan-9-ol, 6'-methoxy-, (9S)-; Conchinin; Conquinine; Pitayine; alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol (9S)-; beta-Quinine; [ChemIDplus]
Category
Plant Toxins
Description
Triboluminescent solid; [Merck Index]
Sources/Uses
Used as a human and veterinary antiarrhythmic and human antimalarial; [Merck Index]
Comments
"Quinidine sulfate has elicited contact allergy in production workers, and patch test with quinine were negative." [Kanerva, p. 435] Quinidine may induce photosensitivity in patients taking it systemically (photodrug reaction). [Marks, p. 201-3] As an oral medication, quinidine is used to treat heart arrhythmias. Many side effects have been reported after ingestion of therapeutic doses, including immune hemolytic anemia and drug-induced hepatitis. [HSDB] Therapeutic serum levels are 2-4 mg/L, and serious adverse effects are unusual in that range. A one gram dose is potentially lethal to adults. Toxic effects include ventricular tachycardia and depression of cardiac contractility. Other symptoms are vomiting, diarrhea, and anticholinergic effects. Seizures and coma may follow. Symptoms of chronic poisoning (cinchonism) are tinnitus, vertigo, deafness, and visual dsturbances. [Olson, p. 356-7]
Adverse Effects
Skin Sensitizer
Yes
Hepatotoxin
Hepatotoxin, Secondary
Links to Other NLM Databases
Toxicity Information
Chemical Information
Biomedical References
Related Information in HazMap