Agent Name

1,1-Dimethylhydrazine

CAS Number

57-14-7

Formula

C2-H8-N2

Major Category

Nitrogen Compounds

Synonyms

Dimazine; DMH; UDMH; Unsymmetrical dimethylhydrazine; [NIOSH]

Category

Hydrazines

Description

Colorless liquid with an ammonia- or fish-like odor; [NIOSH]

Sources/Uses

Used in jet and rocket fuels, photography, and organic synthesis; also used to control plant growth and to absorb acid gases; [ACGIH]

Comments

Liquid causes second or third degree burns after short contact; [CHRIS] Corrosive to skin; [Quick CPC] In animal experiments at 5 ppm, 6 hours/day, 5 days a week, 1,1-dimethylhydrazine causes neurological injury and hemolytic anemia. In several reported cases following industrial accidents, observed effects included neurological symptoms, pulmonary edema, and elevated liver enzymes. [ACGIH] Patients poisoned by hydrazines may develop methemoglobinemia and liver injury. [HSDB] In high-dose reproductive studies of animals, hydrazine derivatives (hydrazine, MMH, and UDMH) cause testicular damage and fetal loss, and hydrazine causes birth defects. [Frazier, p. 341-2] Danger of skin sensitization; [MAK]

Reference Link

ATSDR - ToxFAQs - Hydrazines

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

TLV (ACGIH)

0.01 ppm

PEL (OSHA)

0.5 ppm

IDLH (NIOSH)

15 ppm

Excerpts from Documentation for IDLHs

Other animal data: No adverse effects were noted in dogs exposed at 50, 200, and 600 ppm for 60, 15, and 5 minutes, respectively; only mild toxic responses were noted at 100, 400, and 1,200 ppm for 60, 15, and 5 minutes, respectively [Weeks et al. 1963].

Vapor Pressure

157 mm Hg

Odor Threshold Low

6.1 ppm

Odor Threshold High

14 ppm

Lethal Concentration

LC50 (rat) = 252 ppm/4 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 9.2);

Reference Link

ICSC: 1,1-Dimethylhydrazine

Flammability (NFPA)

4: Burns readily

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: