Agent Name

5-Nitro-2-toluidine

Alternative Name

Nitro-o-toluidine

CAS Number

99-55-8

Formula

C7-H8-N2-O2

Major Category

Nitrogen Compounds

Synonyms

Nitro-o-toluidine; AI3-01557; Amarthol Fast Scarlet G Base; Amarthol Fast Scarlet G Salt; 2-Amino-4-nitrotoluene; Azoene Fast Scarlet GC Base; Azoene Fast Scarlet GC Salt; Azofix Scarlet G Salt; Azogene Fast Scarlet G; Benzenamine, 2-methyl-5-nitro-; CI Azoic Diazo Component 12; CI 37105; Dainichi Fast Scarlet G Base; Daito Scarlet Base G; Devol Scarlet B; Devol Scarlet G Salt; Diabase Scarlet G; Diazo Fast Scarlet G; Fast Red SG Base; Fast Scarlet G; Fast Scarlet G Base; Fast Scarlet Base J; Fast Scarlet T Base; Fast Scarlet M4NT Base; Fast Scarlet GC Base; Fast Scarlet G Salt; Fast Scarlet J Salt; Hiltonil Fast Scarlet G Base; Hiltonil Fast Scarlet GC Base; Hiltonil Fast Scarlet G Salt; Kayaku Scarlet G Base; Lake Scarlet G Base; Lithosol Orange R Base; 2-Methyl-5-nitroaniline; 6-Methyl-3-nitroaniline; 2-Methyl-5-nitro-benzenamine; Mitsui Scarlet G Base; Naphthanil Scarlet G Base; Naphtoelan Fast Scarlet G Base; Naphtoelan Fast Scarlet G Salt; 4-Nitro-2-aminotoluene; 3-Nitro-6-methylaniline; PNOT; Scarlet G Base; Scarlet Base Ciba II; Scarlet Base IRGA II; Scarlet Base NSP Sugai Fast Scarlet G Base; Symulon Scarlet G Base; o-Toluidine, 5-nitro-; Nitro-o-toluidine; [HSDB] 4-Nitro-2-aminotoluene; [Guide to Occupational Exposure Values, 2002] UN2660

Category

Nitroanilines

Description

Yellow crystals; [ACGIH]

Sources/Uses

Workers are exposed during production or handling of more than 35 commercial dyes (orange or red) of which 5-nitro-o-toluidine is the major component; [ACGIH]

Comments

Several Japanese workers were admitted to the hospital with severe liver damage after handling repeatedly (12-20 times) 5-nitro-o-toluidine for 4-5 hours at a time. Workers had scooped the powder by hand while wearing respirators. [Gut 2002 Feb;50(2):266-70] Methemoglobinemia is a potential adverse effect after exposure to this agent. [HSDB]

Reference Link

Liver dysfunction among workers handling 5-nitro-o-toluidine

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

1 mg/m3, inhalable fraction

Vapor Pressure

0.000975 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Primary

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: