Agent Name

Isobutyl nitrite

CAS Number

542-56-3

Formula

C4-H9-N-O2

Major Category

Nitrogen Compounds

Synonyms

Blackjack; IBN; Isobutyl nitrite; Nitrous acid, 2-methylpropyl ester; Nitrous acid, isobutyl ester; [ChemIDplus] UN1992

Category

Nitrates and Nitrites

Description

Clear colorless to pale yellow liquid; [CAMEO]

Sources/Uses

Used as a chemical intermediate and a drug for angina pectoris; [ACGIH] Amyl nitrite and isobutyl nitrite are used as illicit, aphrodisiac inhalants to enhance erection. [AHLS, p. 199]

Comments

High doses cause death from methemoglobinemia in acute and subchronic animal studies. [ACGIH] Liver damage as a cause of death was suggested in one animal study. [HSDB] A volatile substance that may be abused by inhalation mainly for its vasodilator properties; [Reference #1]

Reference Link

Volatile Substance Abuse

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Insufficient data

Ceiling (ACGIH)

1 ppm, inhalable fraction and vapor

Vapor Pressure

10 mm Hg

Lethal Concentration

LC50 (rat) = 777 ppm/4h

Explanatory Notes

Flash point = -10 deg F;

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

No other related information on this agent was found.