Agent Name

Phenylhydrazine

CAS Number

100-63-0

Formula

C6-H8-N2

Major Category

Nitrogen Compounds

Synonyms

Fenilidrazina [Italian]; Fenylhydrazine [Dutch]; Hydrazine, phenyl-; Hydrazine-benzene; Hydrazinobenzene; Hydrazobenzene; Monophenylhydrazine; Phenylhydrazin [German]; Phenylhydrazine; [ChemIDplus] UN2572

Category

Hydrazines

Description

Colorless to pale-yellow liquid or solid (below 67 degrees F) with a faint, aromatic odor; [NIOSH]

Sources/Uses

Used in the synthesis of dyes and pharmaceuticals; [ACGIH]

Comments

Hemolytic anemia has been observed in workers after inhalation and dermal exposures. [ACGIH] Phenylhydrazine is a potent skin sensitizer and can cause hemolytic anemia by all routes of exposure. Toxic effects were observed in patients treated for polycythemia with doses of 0.2 G/day for 3 or 4 doses, then 0.1 G/day. Adverse effects included hemolytic anemia, liver injury, and methemoglobinemia. [HSDB] Can cause hemolytic anemia and skin sensitization; [ICSC] Causes first-degree burns on short exposure and second-degree burns on prolonged exposure; [CHRIS]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 ppm

PEL (OSHA)

5 ppm

IDLH (NIOSH)

15 ppm

Excerpts from Documentation for IDLHs

No data on acute or chronic inhalation toxicity are available on which to base the IDLH. Systemic effects described by Patty [1963] were caused by chronic exposures from oral dosing. NIOSH [1976] cited a rat oral LD50 of 188 mg/kg [Ekshtat 1965] which provides a calculated estimate of 1,300 mg/m3 (295 ppm) for the IDLH.

Vapor Pressure

0.02 mm Hg

Lethal Concentration

LC50 (rat) = 2,610 mg/m3

Explanatory Notes

Flash point = 88 deg C;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Anemia

Anemia, Hemolytic

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: