Agent Name

Fluorescein isothiocyanate

Alternative Name

FITC

CAS Number

27072-45-3

Formula

C21-H11-N-O5-S

Major Category

Dyes

Synonyms

FITC; Fluorescein-5(or 6)-isothiocyanate; 3',6'-Dihydroxy-5(or 6)-isothiocyanatospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-5(or 6)-isothiocyanato-; [ChemIDplus] Fluorescein 5(6)-isothiocyanate; [Sigma-Aldrich MSDS]

Category

Other Dyes

Description

Orange solid; [Merck Index] Dark yellow powder; [Sigma-Aldrich MSDS]

Sources/Uses

Used as a fluorescent indicator to probe biological systems and monitor sewage; [Merck Index]

Comments

A mixture of the 5- and 6-isothiocyante isomers; [Merck Index] A skin sensitizer in animal expperiments; [Refeence #1] May cause irritation, respiratory sensitization, and lung injury; [Sigma-Aldrich MSDS] See "Fluorescein-5-isothiocyanate." See "Fluorescein."

Reference Link

Transient receptor potential ankyrin 1 activation enhances hapten sensitization in a T-helper type 2-driven fluorescein isothiocyanate-induced contact hypersensitivity mouse model.

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: