Agent Name

Fluorobenzene

CAS Number

462-06-6

Formula

C6-H5-F

Major Category

Solvents

Synonyms

Monofluorobenzene; Phenyl fluoride; Benzene, fluoro-; [ChemIDplus] Benzene fluoride; MFB; [CAMEO] UN2387

Category

Chlorinated Aromatics

Description

Liquid with an odor of benzene; [Merck Index] Colorless liquid with an aromatic odor; [Alfa Aesar MSDS]

Sources/Uses

Used to control carbon content in steel manufacturing, as an identification reagent for plastic and resin polymers, and as an intermediate for insecticides and larvicides; [NTP] Used as an intermediate for pharmaceuticals, pesticides, and other organic compounds; [ToxPlanet: EPA - PPRTV]

Comments

Causes general anesthesia in inhalation lethal-concentration studies of mice; [RTECS] A 28-day inhalation study of rats produced adaptive liver changes (not considered toxicologically significant), and increased fluoride concentrations in bones and teeth; Not likely to cause developmental toxicity or teratogenicity, based on software modeling and a structurally similar compound (chlorobenzene); [EPA ChAMP: Submissions - Submission] May cause smarting and reddening of skin if spilled and allowed to remain on clothes; Vapor exposure may cause coughing, transient anesthesia, and CNS depression; Chronic inhalation exposure may cause lung, liver, and kidney injury; [CHRIS] A skin, eye, nose, and throat irritant; [ToxPlanet: FAHG] An irritant; [NTP] A mild skin and strong eye irritant; Vapors may cause narcotic effects; [Alfa Aesar MSDS] See "Chlorobenzene."

Exposure Assessment
Vapor Pressure

77.2 mm Hg

Lethal Concentration

LC50 (rat) = 26,908 mg/m3

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: