Agent Name

Cyclohexanone

CAS Number

108-94-1

Formula

C6-H10-O

Major Category

Solvents

Synonyms

Anon; Anone; Cyclohexanone; Cyclohexyl ketone; Hexanon; Hytrol O; Ketohexamethylene; Nadone; Pimelic ketone; Pimelin ketone; Sextone; [ChemIDplus] UN1915

Category

Ketones (<C12)

Description

Water-white to pale-yellow liquid with a peppermint- or acetone-like odor; [NIOSH]

Sources/Uses

Has many uses as an industrial solvent; used as a paint remover and in printing inks; [ACGIH]

Comments

Liquid causes first degree burns on short exposure; [CHRIS] Animals become stuporous in high-dose inhalation studies and develop liver necrosis after high-dose feeding studies. [ACGIH] [Sanmartin O, et al. Occupational contact dermatitis from cyclohexanone as a PVC adhesive. Contact Dermatitis. 1992 Sep;27(3):189-90. No abstract available. Abstract in NIOSHTIC #179644]

Reference Link

Contact allergy to a cyclohexanone resin in humans and guinea pigs

Exposure Assessment
BEI

1,2-Cyclohexanediol (with hydrolysis) in urine: 80 mg/L (end of shift at end of workweek); Cyclohexanol (with hydrolysis) in urine: 8 mg/L (end of shift); See notations in ACGIH TLVs and BEIs.

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

20 ppm

PEL (OSHA)

50 ppm

IDLH (NIOSH)

700 ppm

Excerpts from Documentation for IDLHs

It has been reported that exposure to 75 ppm for 3 to 5 minutes has resulted in pronounced irritation of the eyes, nose, and throat [Nelson et al. 1943].

Vapor Pressure

5 mm Hg

Odor Threshold Low

0.12 ppm

Odor Threshold High

100 ppm

RD50

756 ppm

Lethal Concentration

LC50 (rat) = 8,000 ppm/4 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 3.5 ppm); Flash point = 44 deg C;

Half Life

For 1,2-cyclohexanediol and 1,4-cyclohexanediol: 14-22 hours; [TDR, p. 434]

Reference Link

ICSC: Cyclohexanone

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: