Agent Name

1,4-Dithiothreitol

CAS Number

3483-12-3

Formula

C4-H10-O2-S2

Major Category

Other Uses

Synonyms

Cleland reagent; Cleland's reagent; D-1,4-Dithiothreitol; D-threo-1,4-Dimercapto-2,3-butanediol; Dithiothreitol; Dithiotreitol; Sputolysin; Threitol, 1,4-dithio-; WR 34678; (R*,R*)-(1)-1,4-Dimercaptobutane-2,3-diol; (R*,R*)-1,4-Dimercaptobutane-2,3-diol; 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-; 2,3-Butanediol, 1,4-dimercapto-, D-threo-; [ChemIDplus] (2R,3R)-rel-1,4-Dimercapto-2,3-butanediol; threo-2,3-Dihydroxy-1,4-dithiolbutane; [Merck Index] DTT; [Sigma-Aldrich MSDS]

Category

Biochemical Research

Description

Slightly hygroscopic solid; [Merck Index] White powder; [Sigma-Aldrich MSDS]

Sources/Uses

Used as a reagent in biochemistry to prevent oxidation of thiol groups and to reduce disulfides to dithiols; [ChemIDplus] Has been used as a radioprotectant; [REPROTOX] "Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent." [Wikipedia]

Comments

Causes convulsions in intramuscular lethal-dose studies of mice (LD50 = 108 mg/kg); [RTECS] A skin and strong eye irritant; May cause CNS depression; Toxic by ingestion; [Sigma-Aldrich MSDS]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

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