Agent Name

Chromium trioxide

Alternative Name

Chromium anhydride

CAS Number

1333-82-0

Formula

Cr-O3

Major Category

Metals

Synonyms

Chromium anhydride; Anhydride chromique [French]; Anidride cromica [Italian]; Chrome (trioxyde de) [French]; Chromia (CrO3); Chromic acid, solid; Chromic anhydride; Chromic oxide; Chromic(VI) acid; Chromium oxide; Chromium oxide (Cr4O12); Chromium oxide (CrO3); Chromium trioxide; Chromium(6+) oxide; Chromium(6+) trioxide; Chromium(VI) oxide; Chromsaeureanhydrid [German]; Chromtrioxid [German]; Chroomtrioxyde [Dutch]; Chroomzuuranhydride [Dutch]; Cromo(triossido di) [Italian]; Monochromium trioxide; Puratronic chromium trioxide; Sintered chromium trioxide; [ChemIDplus] UN1463

Category

Chromium Compounds, Inorganic

Description

Dark red to brown crystals, flakes, or powder; [HSDB] Soluble in water; [ACGIH]

Sources/Uses

Used in chromium plating, copper stripping, and aluminum anodizing; also used to inhibit corrosion, to develop photographs, to purify oil and acetylene, to harden microscopic preparations, and to oxidize organic chemicals; [HSDB] Used in sulfuric acid as a photoresist stripper; [CSH, p. 49] Also used as a wood preservative; [ACGIH]

Comments

CrVI compounds are irritants, sensitizers, and may be corrosive to the skin. CrVI compounds are respiratory tract irritants and may cause pulmonary sensitization. CrVI may cause acute tubular necrosis and liver injury. [ATSDR Case Studies] Highly corrosive to skin; [Quick CPC] Chromium trioxide (chromic acid) is a water-soluble hexavaent chromium compounds. A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; May cause skin sensitization, kidney injury, and asthma after prolonged contact; [ICSC] See "Chromium" and linked occupational diseases.

Exposure Assessment
Skin Designation (ACGIH)

Yes

Bioaccumulates

Yes

TLV (ACGIH)

0.0002 mg/m3, as Cr(VI), inhalable particulate matter

STEL (ACGIH)

0.0005 mg/m3, as Cr(VI), inhalable particulate matter

PEL (OSHA)

0.005 mg/m3, as Cr(VI)

Lethal Concentration

LC50 (rat) = 167 mg/m3/4 H; [CHEMINFO]

Explanatory Notes

Melting point = 197 degrees C; [HSDB] The Guide from the Emergency Response Guidebook is for "Chromium trioxide, anhydrous."

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

ACGIH Carcinogen

Confirmed Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: