Agent Name

Diacetone alcohol

Alternative Name

4-Hydroxy-4-methyl-2-pentanone

CAS Number

123-42-2

Formula

C6-H12-O2

Major Category

Solvents

Synonyms

4-Hydroxy-4-methyl-2-pentanone; 2-Methyl-2-pentanol-4-one; 2-Pentanone, 4-hydroxy-4-methyl-; 4-Hydroxy-2-keto-4-methylpentane; 4-Hydroxy-4-methyl pentan-2-one; 4-Hydroxy-4-methylpentanone-2; Acetonyldimethylcarbinol; Diacetone; Diacetone alcohol; Diacetonyl alcohol; Diketone alcohol; Dimethyl acetonyl carbinol; Pyranton; Pyranton A; Tyranton; [ChemIDplus] UN1148

Category

Other Solvents

Description

Colorless liquid with a faint, minty odor; [NIOSH]

Sources/Uses

Used in antifreeze and brake fluids; also used as a solvent to make nitrocellulose, cellulose acetate, celluloid, pigments, waxes, and oils; [ACGIH]

Comments

Narcosis induced in animal inhalation studies; [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

50 ppm

PEL (OSHA)

50 ppm

MAK

20 ppm

IDLH (NIOSH)

1800 ppm

Excerpts from Documentation for IDLHs

It has been reported that eye irritation appeared in volunteers exposed for 15 minutes at 100 ppm [Silverman et al. 1946].

Vapor Pressure

1.71 mm Hg

Odor Threshold Low

0.27 ppm

Odor Threshold High

1.1 ppm

Lethal Concentration

LCLo (rat) = 1,000 ppm/4h

Explanatory Notes

IDLH = 10% LEL (lower explosive limit); Detection odor threshold from AIHA (mean = 0.27 ppm); Flash point = 66 deg C;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: