Agent Name

1,4-Dichloro-2-butene

CAS Number

764-41-0

Formula

C4-H6-Cl2

Major Category

Other Classes

Synonyms

1,4-DCB; 1,4-Dichloro-2-butylene; 1,4-Dichlorobutene-2; 2-Butene, 1,4-dichloro-; 2-Butylene dichloride; 1,4-Dichlorobut-2-ene; [ChemIDplus] UN2920

Category

Halogenated Aliphatics, Unsaturated

Description

Colorless liquid with a sweet, pungent odor; [HSDB] Yellowish liquid; [OECD SIDS]

Sources/Uses

Used as an intermediate in chemical manufacturing; [HSDB] Continuously manufactured and processed in closed systems and essentially used 100% as an intermediate; [OECD SIDS]

Comments

Highly toxic; [Quick CPC] When heated, decomposes to toxic gases: phosgene and HCl; High inhalation exposure can cause pulmonary edema; [HSDB] Skin contact with liquid causes severe blistering; [CHRIS] Induces genetic damage in germ cells of humans or animals (3A); [MAK] Reacts with water forming hydrochloric acid; Vapor is irritating to nose and throat; Highly irritating to skin (blistering) and eyes (lachrymation); [CAMEO] Generally available in the US as a mixture of 95-98% trans- (CAS# 110-57-6) and 2-5% cis- (CAS#1476-11-5) isomers; [OECD SIDS] Causes burns and lachrymation; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Highly toxic by inhalation; Toxic by ingestion and skin absorption; [Aldrich MSDS] See "1,4-Dichloro-trans-2-butene."

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.005 ppm

Vapor Pressure

3 mm Hg

Lethal Concentration

LC50 (rat) = 86 ppm/4hr

Explanatory Notes

LC50 (rat) = 450 mg/m3/4hr; [OECD SIDS] The Guide in the Emergency Response Guidebook is for "Dichlorobutene."

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Suspected Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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