Agent Name

Diisobutyl ketone

Alternative Name

2,6-Dimethyl-4-heptanone

CAS Number

108-83-8

Formula

C9-H18-O

Major Category

Solvents

Synonyms

2,6-Dimethyl-4-heptanone (natural);2,6-Dimethylheptan-4-one; 2,6-Dimethylheptanone; 4-Heptanone, 2,6-dimethyl-; DIBK; Diisobutyl ketone; Isobutyl ketone; Isovalerone; Valerone; s-Diisopropylacetone; sec-Diisopropyl acetone; sym-Diisopropylacetone; [ChemIDplus] UN1157

Category

Ketones (<C12)

Description

Colorless liquid with a mild, sweet odor; [NIOSH]

Sources/Uses

"Mainly used as coating solvent"; [HSDB]

Comments

Humans experience offensive irritating effects below concentrations that cause CNS depression in experimental animals. [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

25 ppm

PEL (OSHA)

50 ppm

IDLH (NIOSH)

500 ppm

Excerpts from Documentation for IDLHs

Human data: It has been reported that a 3hour exposure at 50 or 100 ppm caused slight irritation to the eyes, nose, and throat [Smyth et al. 1949].

Vapor Pressure

1.65 mm Hg

Odor Threshold Low

0.11 ppm

Odor Threshold High

0.31 ppm

Lethal Concentration

LCLo (rat) = 2,000 ppm/4H

Explanatory Notes

Odor threshold (detection at 0.11 ppm and recognition at 0.31 ppm) from CHEMINFO; Flash point = 49 deg C;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: