Agent Name

Ethionine

CAS Number

13073-35-3

Formula

C6-H13-N-O2-S

Major Category

Other Uses

Synonyms

(L)-Ethionine; Butanoic acid, 2-amino-4-(ethylthio)-, (S)-; ETH; Homocysteine, S-ethyl-; L-2-Amino-4-(ethylthio)butyric acid; L-Ethionine; L-Homocysteine, S-ethyl-; L-S-Ethylhomocysteine; Butyric acid, 2-amino-4-(ethylthio)-, L-; S-Ethyl-L-homocysteine; [ChemIDplus] Homocysteine S-ethyl ether; [Merck Index]

Category

Biochemical Research

Description

Solid; [Merck Index]

Sources/Uses

"An antimetabolite and methionine antagonist that interferes with amino acid incorporation into proteins and with cellular ATP utilization. It also produces liver neoplasms." [ChemIDplus] Toxic analogue of the essential amino acid methionine; Produced by various microorganisms such as E. coli; Used as an experimental carcinogen and in biological research; Not commercially produced in the US; [HSDB]

Comments

Causes diffuse hepatitis and acute renal failure in acute oral studies of rats; Causes hepatitis in 35-day constant oral studies of rats; [RTECS] A hepatotoxin; [HSDB] A skin and strong eye irritant; Targets the liver; [Sigma-Aldrich MSDS]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

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Toxicity Information

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Chemical Information

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Other Information

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