Agent Name

Isophorone

CAS Number

78-59-1

Formula

C9-H14-O

Major Category

Other Classes

Synonyms

1,1,3-Trimethyl-3-cyclohexene-5-one; 2-Cyclohexen-1-one, 3,5,5-trimethyl-; 3,5,5-Trimethyl-2-cyclohexen-1-on [German, Dutch]; 3,5,5-Trimethyl-2-cyclohexen-1-one; 3,5,5-Trimethyl-2-cyclohexenone; 3,5,5-Trimetil-2-cicloesen-1-one [Italian]; Isoacetophorone; Isoforon; Isoforone [Italian]; Isooctopherone; Isophorone; Izoforon [Polish]; [ChemIDplus] UN8027

Category

Aliphatic Ketones, Other

Description

Colorless to white liquid with a peppermint-like odor; [NIOSH]

Sources/Uses

Used as a solvent for coatings, especially vinyl resins applied by roller; also used as a chemical intermediate and a solvent for other materials; [ACGIH]

Comments

Liquid causes first degree burns on short exposure. [CHRIS] Isophorone is a skin irritant. [Quick CPC]

Reference Link

ATSDR ToxFAQs - Isophorone

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

Ceiling (ACGIH)

5 ppm

PEL (OSHA)

25 ppm

MAK

2 ppm

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that exposure of animals for 1 hour to 880 ppm caused serious organ damage; only 1 of 6 animals died from an 8hour exposure to air saturated with isophorone (approximately 525 ppm at 77F). . . . Human data: A few of the 11 or 12 volunteers exposed for a few minutes to 200 or 400 ppm complained of nausea, headache, dizziness, faintness, inebriation, and a feeling of suffocation [Smyth and Seaton 1940].

Vapor Pressure

0.43 mm Hg

Odor Threshold Low

0.19 ppm

Odor Threshold High

0.53 ppm

RD50

27 ppm

Lethal Concentration

LC50 (rat) = 7,000 mg/m3/4h

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.19 ppm); Flash point = 84 deg C;

Reference Link

ICSC: Isophorone

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: