Agent Name

Isophorone

CAS Number

78-59-1

Formula

C9-H14-O

Major Category

Other Classes

Synonyms

1,1,3-Trimethyl-3-cyclohexene-5-one; 2-Cyclohexen-1-one, 3,5,5-trimethyl-; 3,5,5-Trimethyl-2-cyclohexen-1-on [German, Dutch]; 3,5,5-Trimethyl-2-cyclohexen-1-one; 3,5,5-Trimethyl-2-cyclohexenone; 3,5,5-Trimetil-2-cicloesen-1-one [Italian]; Isoacetophorone; Isoforon; Isoforone [Italian]; Isooctopherone; Isophorone; Izoforon [Polish]; [ChemIDplus] UN8027

Category

Aliphatic Ketones, Other

Description

Colorless to white liquid with a peppermint-like odor; [NIOSH]

Sources/Uses

Used as a solvent for coatings, especially vinyl resins applied by roller; also used as a chemical intermediate and a solvent for other materials; [ACGIH]

Comments

Liquid causes first degree burns on short exposure. [CHRIS] Isophorone is a skin irritant. [Quick CPC]

Reference Link

ATSDR ToxFAQs - Isophorone

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

Ceiling (ACGIH)

5 ppm

PEL (OSHA)

25 ppm

MAK

2 ppm

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that exposure of animals for 1 hour to 880 ppm caused serious organ damage; only 1 of 6 animals died from an 8hour exposure to air saturated with isophorone (approximately 525 ppm at 77F). . . . Human data: A few of the 11 or 12 volunteers exposed for a few minutes to 200 or 400 ppm complained of nausea, headache, dizziness, faintness, inebriation, and a feeling of suffocation [Smyth and Seaton 1940].

Vapor Pressure

0.43 mm Hg

Odor Threshold Low

0.19 ppm

Odor Threshold High

0.53 ppm

RD50

27 ppm

Lethal Concentration

LC50 (rat) = 7,000 mg/m3/4h

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.19 ppm); Flash point = 84 deg C;

Reference Link

ICSC: Isophorone

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: