Agent Name | Methyl vinyl ketone |
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Alternative Name | 3-Buten-2-one |
CAS Number | 78-94-4 |
Formula | C4-H6-O |
Major Category | Toxic Gases & Vapors |
Synonyms | 3-Buten-2-one; 1-Buten-3-one; 2-Butenone; 3-Butene-2-one; 3-Butenone-2; Acetone, methylene-; Acetyl ethylene; Butenone; Ketone, methyl vinyl; Methyl ethenyl ketone; Methyl-vinyl-cetone [French]; Methylene acetone; Methylvinyl ketone; Methylvinylketon [German]; Methylvinylketone; Vinyl methyl ketone; delta(sup 3)-2-Butenone; gamma-Oxo-alpha-butylene; Methyl vinyl ketone, stabilized; [ChemIDplus] UN1251 |
Category | Other Toxic Gases & Vapors |
Description | Colorless liquid with a pungent odor; [HSDB] Colorless to pale yellow liquid with a strong irritating odor; [CHRIS] |
Sources/Uses | Used as an intermediate in chemical synthesis, an alkylating agent, and a monomer in resins; it is present in cigarette smoke; [HSDB] |
Comments | Highly toxic; [Quick CPC] A lachrymator; Can cause liver injury (animal studies); Potential for pulmonary edema after heavy inhalation exposure; [HSDB] Causes lachrymation; May cause skin sensitization; [ICSC] Liquid causes second or third degree burns on short contact; [CHRIS] May polymerize exothermically if heated, exposed to sunlight, or contaminated; [CAMEO] Danger of skin sensitization; [MAK] A severe skin irritant (1% solution); Causes acute pulmonary edema, emphysema, and other liver changes in inhalation lethal-concentration studies of rats; Causes impaired liver function tests in repeated-dose inhalation studies of rats; [RTECS] |
Exposure Assessment | |
Skin Designation (ACGIH) | Yes |
TIH | Yes |
Ceiling (ACGIH) | 0.2 ppm |
Vapor Pressure | 83.9 mm Hg |
Odor Threshold Low | 0.2 ppm |
Lethal Concentration | LC50 (rat) = 7 mg/m3/4hr |
Flammability (NFPA) | |
Adverse Effects | |
Skin Sensitizer | Yes |
Lacrimator | Yes |
Toxic Pneumonitis | Yes |
Hepatotoxin | Hepatotoxin, Secondary |
Dermatotoxin | Skin Burns |
Links to Other NLM Databases | |
Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
Toxicity Information | |
Chemical Information | |
Related Information in HazMap | |
Diseases | Occupational diseases associated with exposure to this agent: |
Activities | Activities with risk of exposure: |