Agent Name

Methyl vinyl ketone

Alternative Name

3-Buten-2-one

CAS Number

78-94-4

Formula

C4-H6-O

Major Category

Toxic Gases & Vapors

Synonyms

3-Buten-2-one; 1-Buten-3-one; 2-Butenone; 3-Butene-2-one; 3-Butenone-2; Acetone, methylene-; Acetyl ethylene; Butenone; Ketone, methyl vinyl; Methyl ethenyl ketone; Methyl-vinyl-cetone [French]; Methylene acetone; Methylvinyl ketone; Methylvinylketon [German]; Methylvinylketone; Vinyl methyl ketone; delta(sup 3)-2-Butenone; gamma-Oxo-alpha-butylene; Methyl vinyl ketone, stabilized; [ChemIDplus] UN1251

Category

Other Toxic Gases & Vapors

Description

Colorless liquid with a pungent odor; [HSDB] Colorless to pale yellow liquid with a strong irritating odor; [CHRIS]

Sources/Uses

Used as an intermediate in chemical synthesis, an alkylating agent, and a monomer in resins; it is present in cigarette smoke; [HSDB]

Comments

Highly toxic; [Quick CPC] A lachrymator; Can cause liver injury (animal studies); Potential for pulmonary edema after heavy inhalation exposure; [HSDB] Causes lachrymation; May cause skin sensitization; [ICSC] Liquid causes second or third degree burns on short contact; [CHRIS] May polymerize exothermically if heated, exposed to sunlight, or contaminated; [CAMEO] Danger of skin sensitization; [MAK] A severe skin irritant (1% solution); Causes acute pulmonary edema, emphysema, and other liver changes in inhalation lethal-concentration studies of rats; Causes impaired liver function tests in repeated-dose inhalation studies of rats; [RTECS]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

Ceiling (ACGIH)

0.2 ppm

Vapor Pressure

83.9 mm Hg

Odor Threshold Low

0.2 ppm

Lethal Concentration

LC50 (rat) = 7 mg/m3/4hr

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Activities

Activities with risk of exposure: