Agent Name

Piperidine

Alternative Name

Hexahydropyridine

CAS Number

110-89-4

Formula

C5-H11-N

Major Category

Nitrogen Compounds

Synonyms

Hexahydropyridine; Azacyclohexane; Cyclopentimine; Cypentil; Hexazane; Pentamethyleneimine; Pentamethylenimine; Perhydropyridine; Piperidin [German]; Pyridine, hexahydro-; [ChemIDplus] UN2401

Category

Amines, Cyclic

Description

Colorless liquid with an amine odor; [HSDB]

Sources/Uses

Used as a chemical intermediate to produce drugs, wetting agents, and disinfectants; Also used as a rubber accelerator, a curing agent for epoxy resins, a flavoring agent, and an additive to oils and fuels; [HSDB]

Comments

Corrosive to skin; [Quick CPC] High inhalation exposure can cause pulmonary edema; [ICSC] Signs of toxicity in acute animal studies included respiratory distress, ataxia, weakness, paralysis, and convulsions; For humans, the irritation threshold is 26 ppm; workers can tolerate levels of 2-5 ppm for only a short period because of the odor; [AIHA] Oral doses of 30-60 mg/kg may cause weakness, vomiting, labored respiration, muscular paralysis, and asphyxia; [NTP] Safe when used as a flavoring agent in food; [JECFA] A skin sensitizer in guinea pigs; [EPA ChAMP] Causes impaired liver function tests in repeated dose inhalation studies of rats; [RTECS]

Exposure Assessment
WEEL

1 ppm

Vapor Pressure

32.1 mm Hg

Lethal Concentration

LC50 (mice) = 6,000 mg/m3/2hr

Explanatory Notes

Odor threshold <2 ppm by volume; [AIHA]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: