Agent Name

Piperidine

Alternative Name

Hexahydropyridine

CAS Number

110-89-4

Formula

C5-H11-N

Major Category

Nitrogen Compounds

Synonyms

Hexahydropyridine; Azacyclohexane; Cyclopentimine; Cypentil; Hexazane; Pentamethyleneimine; Pentamethylenimine; Perhydropyridine; Piperidin [German]; Pyridine, hexahydro-; [ChemIDplus] UN2401

Category

Amines, Cyclic

Description

Colorless liquid with an amine odor; [HSDB]

Sources/Uses

Used as a chemical intermediate to produce drugs, wetting agents, and disinfectants; Also used as a rubber accelerator, a curing agent for epoxy resins, a flavoring agent, and an additive to oils and fuels; [HSDB]

Comments

Corrosive to skin; [Quick CPC] High inhalation exposure can cause pulmonary edema; [ICSC] Signs of toxicity in acute animal studies included respiratory distress, ataxia, weakness, paralysis, and convulsions; For humans, the irritation threshold is 26 ppm; workers can tolerate levels of 2-5 ppm for only a short period because of the odor; [AIHA] Oral doses of 30-60 mg/kg may cause weakness, vomiting, labored respiration, muscular paralysis, and asphyxia; [NTP] Safe when used as a flavoring agent in food; [JECFA] A skin sensitizer in guinea pigs; [EPA ChAMP] Causes impaired liver function tests in repeated dose inhalation studies of rats; [RTECS]

Exposure Assessment
WEEL

1 ppm

Vapor Pressure

32.1 mm Hg

Lethal Concentration

LC50 (mice) = 6,000 mg/m3/2hr

Explanatory Notes

Odor threshold <2 ppm by volume; [AIHA]

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: