Agent Name

Pyrrolidine

Alternative Name

Tetramethyleneimine

CAS Number

123-75-1

Formula

C4-H9-N

Major Category

Nitrogen Compounds

Synonyms

1-Azacyclopentane; Azacyclopentane; Azolidine; Butylenimine; Perhydropyrrole; Prolamine; Pyrrole, tetrahydro-; Pyrrolidine ring; Tetrahydropyrrole; Tetramethyleneimine; [ChemIDplus] UN1922

Category

Amines, Cyclic

Description

Colorless to yellow liquid with ammonia-like odor; [HSDB]

Sources/Uses

Used as an intermediate in chemical production and as a curing agent in epoxy resin systems; [HSDB]

Comments

Corrosive to skin; [Quick CPC] In high-dose animal studies, causes damage to the liver, kidneys, and CNS (seizures); In 6-hour inhalation studies with concentrations of 2600 ppm, no rats died. [HSDB] Corrosive to skin and eyes; A respiratory tract irritant; May have effects on the nervous system; [ICSC] Safe when used as a flavoring agent in food; [JECFA] Causes convulsions in inhalation lethal-concentration studies of mice and oral lethal-dose studies of rats; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion and inhalation; [Alfa Aesar MSDS]

Exposure Assessment
Vapor Pressure

62.69 mm Hg

Lethal Concentration

LC50 (mouse) = 1,300 mg/m3/2hr

Explanatory Notes

Flash point = 37 deg F; [CAMEO]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: