Agent Name

Pyrrolidine

Alternative Name

Tetramethyleneimine

CAS Number

123-75-1

Formula

C4-H9-N

Major Category

Nitrogen Compounds

Synonyms

1-Azacyclopentane; Azacyclopentane; Azolidine; Butylenimine; Perhydropyrrole; Prolamine; Pyrrole, tetrahydro-; Pyrrolidine ring; Tetrahydropyrrole; Tetramethyleneimine; [ChemIDplus] UN1922

Category

Amines, Cyclic

Description

Colorless to yellow liquid with ammonia-like odor; [HSDB]

Sources/Uses

Used as an intermediate in chemical production and as a curing agent in epoxy resin systems; [HSDB]

Comments

Corrosive to skin; [Quick CPC] In high-dose animal studies, causes damage to the liver, kidneys, and CNS (seizures); In 6-hour inhalation studies with concentrations of 2600 ppm, no rats died. [HSDB] Corrosive to skin and eyes; A respiratory tract irritant; May have effects on the nervous system; [ICSC] Safe when used as a flavoring agent in food; [JECFA] Causes convulsions in inhalation lethal-concentration studies of mice and oral lethal-dose studies of rats; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion and inhalation; [Alfa Aesar MSDS]

Exposure Assessment
Vapor Pressure

62.69 mm Hg

Lethal Concentration

LC50 (mouse) = 1,300 mg/m3/2hr

Explanatory Notes

Flash point = 37 deg F; [CAMEO]

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: