Agent Name

Trifluoroacetic acid

Alternative Name

Perfluoroacetic acid

CAS Number

76-05-1

Formula

C2-H-F3-O2

Major Category

Other Classes

Synonyms

Kyselina trifluoroctova [Czech]; Trifluoracetic acid; Trifluoroethanoic acid; Acetic acid, 2,2,2-trifluoro-; Acetic acid, trifluoro-; Perfluoroacetic acid; [ChemIDplus] UN2699

Category

Organic Acids

Description

Colorless fuming liquid with a pungent odor; [ICSC] Hygroscopic; [HSDB]

Sources/Uses

Used in synthesis of organic chemicals; [Merck Index] Used as a laboratory reagent, solvent, and catalyst; [HSDB]

Comments

Corrosive to skin; [Quick CPC] Corrosive to skin, eyes, and respiratory tract; Inhalation may cause pulmonary edema; [ICSC] A metabolite of halothane (anesthetic) and trifluoroethanol; Unlike trifluoroethanol, trifluoroacetic acid did not produce testicular toxicity in rats at similar doses; [REPROTOX] Causes dyspnea in inhalation lethal-concentration studies of mice and rats; Causes other liver changes in 10-day oral studies of mice; [RTECS] Harmful by inhalation; Causes severe burns; May cause liver damage; Inhalation of high concentration may cause chemical pneumonitis; [Aldrich MSDS] See "Fluoroacetic acid."

Exposure Assessment
Vapor Pressure

107 mm Hg

Lethal Concentration

LC50 (rat) = 10,000 mg/m3

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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