Agent Name

Trifluoromethanesulfonic acid

CAS Number

1493-13-6

Formula

C-H-F3-O3-S

Major Category

Other Classes

Synonyms

Methanesulfonic acid, trifluoro-; Perfluoromethanesulfonic acid; Methanesulfonic acid, 1,1,1-trifluoro-; [ChemIDplus] Triflic acid; TFMSA; [Merck Index] UN3265

Category

Organic Acids

Description

Colorless hygroscopic liquid; [Merck Index]

Sources/Uses

Used as a catalyst, solvent for ESR, acid titrant, and with trifluoroacetic acid in peptide synthesis; [Merck Index]

Comments

Highly corrosive to skin; [Quick CPC] "One of the strongest acids known." May cause burns; [Merck Index] Oral LD50 (rat) is between 500 and 2,000 mg/kg; An acute dermal toxicity study of rats at 2,000 mg/kg produced extensive and severe local skin effects considered to be life threatening; 50 mg/kg doses were tolerated and showed no significant adverse effects at necropsy; No evidence of skin sensitization in guinea pigs; No evidence of mutagenicity; [EPA TSCA] Causes burns; Inhalation of high concentration can cause chemical pneumonitis; [Alfa Aesar MSDS]

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Corrosive liquid, acidic, organic, n.o.s."

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Other Information

No other related information on this agent was found.