Agent Name

Guanidine thiocyanate

CAS Number

593-84-0

Formula

C-H5-N3.C-H-N-S

Major Category

Other Uses

Synonyms

Guanidine, monothiocyanate; Guanidinium thiocyanate; Thiocyanic acid, compd. with guanidine (1:1); [ChemIDplus] UN1759

Category

Biochemical Research

Description

White crystalline solid; Hygroscopic; [Sigma-Aldrich MSDS]

Sources/Uses

"A powerful chaotropic agent." [ChemIDplus] "A chaotropic agent is a substance which disrupts the structure of, and denatures, macromolecules such as proteins and nucleic acids (e.g. DNA and RNA)." [Wikipedia] Used for RNA isolation and can solubilize proteins; [Santa Cruz Biotechnology]

Comments

Intraperitoneal LD50 (mouse) = 300 mg/kg; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; [Sigma-Aldrich MSDS] See "Guanidine." See "Sodium thiocyanate."

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Corrosive solid, n.o.s."

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.