Agent Name

2-Hexanone

Alternative Name

Methyl n-butyl ketone

CAS Number

591-78-6

Formula

C6-H12-O

Major Category

Solvents

Synonyms

Butyl methyl ketone; MBK; Methyl butyl ketone; Methyl n-butyl ketone; [NIOSH]

Category

Ketones (<C12)

Description

Colorless liquid with an acetone-like odor; [NIOSH]

Sources/Uses

No longer used in the USA, but used in the past in organic synthesis and as a solvent for inks, coatings, adhesives, oils, waxes, etc; [CHEMINFO]

Comments

The peripheral neuropathy caused by n-hexane and methyl n-butyl ketone is due to the toxic intermediary metabolite, gamma-diketone 2,5-hexanedione. Both of these chemicals have been abused for their acute, euphoric effects. Occupational toxic polyneuropathy was recognized in the 1960s among workers in the shoe and adhesive industries. [LaDou, p. 430] MnBK causes testicular atropy in male rats after exposure to 700 ppm for 11 weeks. [ACGIH]

Restricted

Not currently produced or used in the US; Production ceased in 1979; [ATSDR ToxProfile]

Exposure Assessment
BEI

2,5-Hexanedione (free) in urine = 0.4 mg/L end of shift at end of workweek;

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

STEL (ACGIH)

10 ppm

PEL (OSHA)

100 ppm

MAK

5 ppm

IDLH (NIOSH)

1600 ppm

Excerpts from Documentation for IDLHs

Volunteers exposed to 1,000 ppm reported a strong odor and transient, moderate eye and nasal irritation [DiVencenzo et al. 1978].

Vapor Pressure

11 mm Hg

Odor Threshold Low

0.06 ppm

Odor Threshold High

0.08 ppm

Lethal Concentration

LC50 (rat) = 8,000 ppm/4H

Explanatory Notes

Odor threshold from AIHA; Flash point = 75 deg F; [CHEMINFO]

Half Life

No reports found; [TDR, p. 776]

Reference Link

ATSDR - ToxFAQs - 2-Hexanone

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

Motor Neuropathy

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: