Agent Name

Methyl isoamyl ketone

CAS Number

110-12-3

Formula

C7-H14-O

Major Category

Solvents

Synonyms

2-Hexanone, 5-methyl-; 2-Methyl-5-hexanone; 5-Methyl-2-hexanone; Isoamyl methyl ketone; Isopentyl methyl ketone; Ketone, methyl isoamyl; MIAK; Methyl isoamyl ketone; Methyl isopentyl keton; [ChemIDplus] 5-Methylhexan-2-one; [CAMEO] UN2302

Category

Ketones (<C12)

Description

Colorless, clear liquid with a pleasant, fruity odor; [NIOSH]

Sources/Uses

Uesd as a solvent for nitrocellulose, cellulose acetate, butyrate, acrylics, high-solid coatings, and vinyl copolymers; [HSDB]

Comments

A skin and eye irritant; [CAMEO] Inhalation of high concentrations may cause kidney injury and unconsciousness; [ICSC] Causes liver injury after repeated high-dose inhalation exposures of rats; [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

20 ppm

STEL (ACGIH)

50 ppm

PEL (OSHA)

100 ppm

MAK

10 ppm

Vapor Pressure

5.77 mm Hg

Odor Threshold Low

0.01 ppm

Odor Threshold High

0.04 ppm

Lethal Concentration

LC50 (rat) = 3,813 ppm/6h

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.013 ppm); Flash point = 36 deg C;

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: