Agent Name

Triisobutylaluminum

CAS Number

100-99-2

Formula

C12-H27-Al

Major Category

Metals

Synonyms

Aluminum, triisobutyl-; Aluminum, tris(2-methylpropyl)-; Tibal; Triisobutyl aluminum; Triisobutylalane; Triisobutylaluminium; Triisobutylaluminum; Tris(2-methylpropyl)aluminum; Tris(isobutyl)alane; Tris(isobutyl)aluminum; [ChemIDplus] TIBA; [CHEMINFO MSDS] UN3051

Category

Metals, Organic Compounds

Description

Colorless liquid; [HSDB]

Sources/Uses

Used as a chemical intermediate and a polymerization catalyst to produce polybutadiene, polyisoprene, and polypropylene; [HSDB] Organic aluminum compounds are "some of the most important, highest volume, highest value organometallic compounds in production." [Ullmann]

Comments

In animal studies, heavy inhalation exposure causes CNS depression and dyspnea. [ChemIDplus] Liquid may cause second or third degree burns after brief skin contact. [CHRIS] Inhalation can induce acute pulmonary edema; [CHEMINFO MSDS] Organoaluminum compounds are corrosive; Harmful if absorbed through the skin or inhaled; The butyl alkyls and below are pyrophoric; Aluminum alkyls are eye irritants; [HSDB] Organic aluminum compounds can cause irritation or burns, depending upon concentration; [Ullmann] TLV withdrawn for aluminum alkyls because of inadequate toxicological data; [ACGIH] Pyrophoric; Reacts violently with water evolving flammable gas; [CAMEO] See "Aluminum." See "ORGANOMETALS."

Exposure Assessment
Vapor Pressure

0.13 mm Hg

Lethal Concentration

LCLo (rat) = 8,000 ppm/1hr

Explanatory Notes

TLV withdrawn in 2008 with adoption of "Aluminum metal and insoluble compounds"; TLV not recommended for soluble nor for alkyl Al compounds; [ACGIH] The Guide in the Emergency Response Guidebook is for "Aluminum alkyls."

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: