Agent Name

Triisobutylaluminum

CAS Number

100-99-2

Formula

C12-H27-Al

Major Category

Metals

Synonyms

Aluminum, triisobutyl-; Aluminum, tris(2-methylpropyl)-; Tibal; Triisobutyl aluminum; Triisobutylalane; Triisobutylaluminium; Triisobutylaluminum; Tris(2-methylpropyl)aluminum; Tris(isobutyl)alane; Tris(isobutyl)aluminum; [ChemIDplus] TIBA; [CHEMINFO MSDS] UN3051

Category

Metals, Organic Compounds

Description

Colorless liquid; [HSDB]

Sources/Uses

Used as a chemical intermediate and a polymerization catalyst to produce polybutadiene, polyisoprene, and polypropylene; [HSDB] Organic aluminum compounds are "some of the most important, highest volume, highest value organometallic compounds in production." [Ullmann]

Comments

In animal studies, heavy inhalation exposure causes CNS depression and dyspnea. [ChemIDplus] Liquid may cause second or third degree burns after brief skin contact. [CHRIS] Inhalation can induce acute pulmonary edema; [CHEMINFO MSDS] Organoaluminum compounds are corrosive; Harmful if absorbed through the skin or inhaled; The butyl alkyls and below are pyrophoric; Aluminum alkyls are eye irritants; [HSDB] Organic aluminum compounds can cause irritation or burns, depending upon concentration; [Ullmann] TLV withdrawn for aluminum alkyls because of inadequate toxicological data; [ACGIH] Pyrophoric; Reacts violently with water evolving flammable gas; [CAMEO] See "Aluminum." See "ORGANOMETALS."

Exposure Assessment
Vapor Pressure

0.13 mm Hg

Lethal Concentration

LCLo (rat) = 8,000 ppm/1hr

Explanatory Notes

TLV withdrawn in 2008 with adoption of "Aluminum metal and insoluble compounds"; TLV not recommended for soluble nor for alkyl Al compounds; [ACGIH] The Guide in the Emergency Response Guidebook is for "Aluminum alkyls."

Flammability (NFPA)

4: Burns readily

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: