Agent Name

Acridine mustard

Alternative Name

ICR 170

CAS Number

146-59-8

Formula

C21-H25-Cl2-N3-O.2Cl-H

Major Category

Other Uses

Synonyms

1,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-, 2HCl; 6-Chloro-9-(3-(ethyl-2-chloroethyl)aminopropylamino)-2-methoxyacridine dihydrochloride; 9-(3-(Ethyl(2-chloroethyl)amino)propylamino)-6-chloro-2-methoxyacridine dihydrochloride; ICR 170; ICR-170; 1,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-, dihydrochloride; 6-Chloro-9-((3-((2-chloroethyl)ethylamino)propyl)amino)-2-methoxyacridine dihydrochloride; Acridine, 6-chloro-9-(3-(N-(2-chloroethyl)-N-ethylamino)propylamino)-2-methoxy-, dihydrochloride; [ChemIDplus] UN2811

Category

Biochemical Research

Description

Yellow solid; [CAMEO]

Comments

Intravenous LDLo (mouse) = 5 mg/kg; [RTECS] An irritant; Harmful by ingestion, inhalation, and skin absorption; Risk of irreversible adverse health effects; Possible carcinogen; [Acros Organics MSDS] See "Acridine" and "Acridine orange." See "Nitrogen mustard (HN-2)."

Reference Link

Highly mutable sites for ICR-170-induced frameshift mutations are associated with potential DNA hairpin structures: studies with SUP4 and other Saccharomyces cerevisiae genes.

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic solid, organic, n.o.s."

Links to Other NLM Databases
Toxicity Information

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Other Information

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