Agent Name

Methyl isobutyl ketone

Alternative Name

Hexone

CAS Number

108-10-1

Formula

C6-H12-O

Major Category

Solvents

Synonyms

2-Methyl-4-pentanone; 2-Methylpropyl methyl ketone; 2-Pentanone, 4-methyl-; 4-Methyl-2-oxopentane; 4-Methyl-2-pentanon [Czech]; 4-Methyl-2-pentanone; 4-Methyl-2-pentanone (natural); 4-Methyl-pentan-2-on [Dutch, German]; 4-Metilpentan-2-one [Italian]; Hexanone; Hexon [Czech]; Hexone; Isobutyl methyl ketone; Isobutyl-methylketon [Czech]; Isohexanone; Isopropyl acetone; Isopropylacetone; Ketone, isobutyl methyl; MIBK; Methyl isobutyl ketone; Methyl-isobutyl-cetone [French]; Methylisobutylketon [Dutch, German]; Metilisobutilchetone [Italian]; Metyloizobutyloketon [Polish]; Shell MIBK; [ChemIDplus] UN1245

Category

Ketones (<C12)

Description

Colorless liquid with a pleasant odor; [NIOSH]

Sources/Uses

Used as a solvent in the paint, synthetic resin, adhesive, aircraft, and pharmaceutical manufacturing industries; [ACGIH]

Comments

MIBK is in the list of "Some volatile substances which may be abused by inhalation" published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1] Fatty livers are observed in guinea pigs exposed to lethal concentrations (28,000 ppm). [HSDB] "TLV basis" is eye and respiratory tract irritation and kidney damage. [ACGIH]

Reference Link

Volatile Substance Abuse

Exposure Assessment
BEI

MIBK in urine = 1 mg/L; sample at end of shift; [ACGIH]

Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

20 ppm

STEL (ACGIH)

75 ppm

PEL (OSHA)

100 ppm

MAK

20 ppm

IDLH (NIOSH)

500 ppm

Excerpts from Documentation for IDLHs

Among a group of workers exposed to concentrations of 500 ppm for 20 to 30 minutes and about 80 ppm for the rest of the shift, most experienced irritation of the eyes, nose, and throat, weakness, loss of appetite, headache, nausea, vomiting, and a sore throat [Linari et al. 1964].

Vapor Pressure

19.9 mm Hg

Odor Threshold Low

0.1 ppm

Odor Threshold High

7.8 ppm

Lethal Concentration

LC50 (rat) = 100,000 mg/m3

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.88 ppm); Flash point = 23 deg C;

Half Life

Blood: initial fast phase = 12 minutes, then slow phase = 1 hour; [TDR, p. 886]

Reference Link

IARC 2012: Methyl Isobutyl Ketone

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: