Agent Name

Phenyl isocyanate

CAS Number

103-71-9

Formula

C7-H5-N-O

Major Category

Toxic Gases & Vapors

Synonyms

Benzene, isocyanato-; Carbanil; Fenylisokyanat [Czech]; Isocyanatobenzene; Isocyanic acid, phenyl ester; Karbanil [Czech]; Mondur P; Phenyl carbonimide; Phenylcarbimide; UN2487; [ChemIDplus]

Category

Monoisocyanates

Description

Liquid with an acrid odor; [Merck Index]

Sources/Uses

Used as a chemical intermediate and analytical reagent; [Hawley]

Comments

A lachrymator and strong irritant of the eyes and respiratory tract; [HSDB] No quantitative data from human studies; The lung appears to be the target organ in lethal concentration studies of experimental animals. "The 1-hour LC50 was 12.6 ppm with most deaths recorded 8 to 12 days post-exposure." TLV Basis is upper respiratory tract irritation; Appears to have sensitization potential (skin and respiratory); [ACGIH] Danger of skin and airway sensitization; [MAK]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

TLV (ACGIH)

0.005 ppm

STEL (ACGIH)

0.01 ppm

Vapor Pressure

2.57 mm Hg

Lethal Concentration

LC50 (rat) = 4.6 ppm/4H

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Toxic Pneumonitis

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: