Agent Name

Methyl propyl ketone

Alternative Name

2-Pentanone

CAS Number

107-87-9

Formula

C5-H10-O

Major Category

Solvents

Synonyms

2-Pentanone (natural); Ethyl acetone; Ethylacetone; Methyl n-propyl ketone; Methyl propyl ketone; Methyl-propyl-cetone [French]; Methylpropyl ketone; Metylopropyloketon [Polish]; Propyl methyl ketone; MPK; [ChemIDplus] UN1249

Category

Ketones (<C12)

Description

Colorless to water-white liquid with a characteristic acetone-like odor; [NIOSH]

Sources/Uses

Used as a solvent, a flavoring agent, and in organic synthesis; [ACGIH] Used as a solvent for lacquers and surface coatings; [HSDB]

Comments

Causes CNS depression and fatty degeneration of the liver after inhalation of high doses by experimental animals; A respiratory tract irritant; [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

STEL (ACGIH)

150 ppm

PEL (OSHA)

200 ppm

IDLH (NIOSH)

1500 ppm

Excerpts from Documentation for IDLHs

Exposure to a concentration of 1,500 ppm was associated with complaints of ocular and upper respiratory irritation [Yant et al. 1936].

Vapor Pressure

35.4 mm Hg

Odor Threshold Low

3.1 ppm

Odor Threshold High

13.6 ppm

RD50

12832 ppm

Lethal Concentration

LCLo (rat) = 2,000 ppm/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 7.7 ppm); Flash point equals 7 deg C; [ACGIH]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: