Agent Name

Hydroxyproline

CAS Number

51-35-4

Formula

C5-H9-N-O3

Major Category

Biological Agents

Synonyms

L-Proline, 4-hydroxy-; 4-Hydroxy-L-proline; Hydroxy-L-proline; Hypro; L-4-Hydroxyproline; L-Proline, 4-hydroxy-, trans-; Proline, 4-hydroxy- (VAN); Proline, 4-hydroxy-, L-; trans-4-Hydroxy-L-proline; trans-4-Hydroxyproline; L-4-Hydroxyproline; L-Proline, 4-hydroxy-, (4R)-; [ChemIDplus] (4R)-4-Hydroxy-L-proline; Hyp; Ls-Hydroxyproline; (-)-(2S,4R)-4-Hydroxyproline; 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic acid; [Merck Index]

Category

Amino Acids and Derivatives

Description

Solid; [Merck Index] White crystalline powder; [Alfa Aesar MSDS]

Sources/Uses

An analog of proline and an non-essential amino acid found in collagen; [Merck Index] ""Hydroxyproline is produced by hydroxylation of the amino acid proline by the enzyme prolyl hydroxylase following protein synthesis (as a post-translational modification). The enzyme catalysed reaction takes place in the lumen of the endoplasmic reticulum. Although it is not directly incorporated into proteins, hydroxyproline comprises roughly 4% of all amino acids found in animal tissue, an amount greater than seven other amino acids that are translationally incorporated. Hydroxyproline is a major component of the protein collagen." [Wikipedia]

Comments

May cause irritation; [Alfa Aesar MSDS] See "L-Proline."

Exposure Assessment
Vapor Pressure

1.52E-9 mm Hg

Links to Other NLM Databases
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