Agent Name

Tetrafluoroethylene

CAS Number

116-14-3

Formula

C2-F4

Major Category

Other Classes

Synonyms

1,1,2,2-Tetrafluoroethylene; Ethene, tetrafluoro-; Fluoroplast 4; Perfluoroethene; Perfluoroethylene; TFE; Tetrafluoroethene; Tetrafluoroethylene; Tetrafluoroethylene monomer; UN1081; [ChemIDplus]

Category

Halogenated Aliphatics, Unsaturated

Description

Colorless, odorless gas; [ACGIH]

Sources/Uses

Used to produce polytetrafluoroethylene polymers (Teflon); [ACGIH]

Comments

In acute animal studies, causes kidney injury at concentrations of 2000 to 6000 ppm; In chronic animal studies, causes hepatic tumors and renal degeneration at 156 ppm and malignant liver and kidney tumors at 312 ppm; [ACGIH] A simple asphyxiant at high concentrations; [NJ-HSFS] Tetrafluoroethylene is a skin irritant. [Quick CPC] Causes somnolence in lethal-dose inhalation studies of mice and guinea pigs; [RTECS] Tetrafluoroethylene, stabilized (UN1081) has warning of explosive polymerization; [ERG 2016]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

2 ppm

Lethal Concentration

LC50 (rat) = 40,000 ppm/4H

Explosive Polymerization

Yes

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Other Poison

Simple Asphyxiant

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: