Agent Name

2,4-Pentanedione

Alternative Name

Acetyl acetone

CAS Number

123-54-6

Formula

C5-H8-O2

Major Category

Other Classes

Synonyms

Acetyl acetone; 2,4-Dioxopentane; 2-Propanone, acetyl-; ACAC; Acetoacetone; Acetone, acetyl-; Acetyl 2-propanone; Acetylacetone; Diacetylmethane; Pentan-2,4-dione; Pentanedione; Pentanedione-2,4; UN2310; [ChemIDplus]

Category

Aliphatic Ketones, Other

Description

Colorless to yellow liquid with a pleasant odor; [CHEMINFO MSDS] Rancid odor at room temperature; [ACGIH]

Sources/Uses

Used as a chemical intermediate, solvent, metal chelating agent, lubricant additive, and pesticide; [Hawley] Used as a metal chelator, lubricant additive, corrosion inhibitor, polyolefin modifier, and intermediate; [ACGIH]

Comments

Causes narcosis with an oral LD50 of 575-1000 mg/kg in rats; Rats inhaling 650 ppm six hours five times weekly for 14 weeks show degenerative changes of the brain and thymus; No neurotoxicity at 307 ppm; [ACGIH] Inhalation of high concentrations causes narcosis; [CHEMINFO MSDS]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

25 ppm

MAK

20 ppm

Vapor Pressure

2.96 mm Hg

Lethal Concentration

LCLo (rat) = 1,000 ppm/4H

Half Life

About 10.75 hours in rats; [ACGIH]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: