Agent Name

Tetraethyl lead

CAS Number

78-00-2

Formula

C8-H20-Pb

Major Category

Metals

Synonyms

Lead tetraethy;, TEL; Tetraethylplumbane; [NIOSH]

Category

Metals, Organic Compounds

Description

Colorless liquid (unless dyed red, orange, or blue) with a pleasant, sweet odor. [Note: Main usage is in anti-knock additives for gasoline.] [NIOSH] Flammable, but not pyrophoric and does not react with water; [Sullivan, p. 979]

Sources/Uses

Tetraethyl and tetramethyl lead (CAS # 78-00-2 & 75-74-1), also called alkyl lead, are used as anti-knock agents in gasoline. [ATSDR Case Studies # 1]

Comments

The presenting symptoms of acute alkyl lead intoxication are neurologic: anorexia, insomnia, fatigue, weakness, headache, depression, and irritability. [ATSDR Case Studies # 1] Toxic by ingestion, inhalation, or skin absorption. Overexposure may cause disturbed vision, tremors, seizures, and brain damage. Monitor workers with urinary lead measurements. [ACGIH] CNS effects are seen within hours to days (usually 1-5 days or as long as 14 days after exposure; [HSDB] "Lead compounds, organic" are not classifiable as to carcinogenicity to humans. [IARC] See "ORGANOMETALS." See "Lead" and linked occupational diseases.

Restricted

Organic lead was added to gasoline in the US until January 1996. [ATSDR Case Studies, Lead Toxicity]

Exposure Assessment
Skin Designation (ACGIH)

Yes

Bioaccumulates

Yes

TLV (ACGIH)

0.1 mg/m3, as Pb

PEL (OSHA)

0.07 mg/m3, as Pb

MAK

0.05 mg/m3, as Pb

IDLH (NIOSH)

40 mg/m3, as Pb

Excerpts from Documentation for IDLHs

Human data: It has been stated that 100 mg Pb/m3 for 1 hour may produce illness [Fleming 1963].

Vapor Pressure

0.2 mm Hg

Lethal Concentration

LC50 (rat) = 850 mg/m3/1H

Adverse Effects
Anemia

Anemia, Hemolytic

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Reproductive Toxin

Yes

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: