Agent Name

Isoflurane

CAS Number

26675-46-7

Formula

C3-H2-Cl-F5-O

Major Category

Other Uses

Synonyms

1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether; 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; Aerrane; Aerrane (Veterinary); Compound 469; Forane; Forene; IsoFlo; Isoflurano [INN-Spanish]; Isofluranum [INN-Latin]; R-E 235dal; Terrell; Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-; Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl; Isoflurane [Anaesthetics, volatile]; [ChemIDplus] ISF; Pentafluoran; [RTECS] Isoflurane liquid; Isoflurane USP; [Abbott Laboratories MSDS]

Category

Waste Anesthetic Gases

Description

Clear colorless liquid with a mild odor; [Merck Index] Musty ethereal odor; [Abbott Laboratories MSDS]

Sources/Uses

Used as a special solvent and as an inhalation anesthetic; [Merck Index] "A stable, non-explosive inhalation anesthetic, relatively free from significant side effects." [ChemIDplus]

Comments

A skin, eye, and respiratory tract irritant; May cause CNS and cardiovascular system effects; [ICSC] Occupational asthma confirmed three workers exposed to Sevoflurane and Isoflurane; [Malo] Mice exposed to concentrations of 0.6% for 4hr/day during gestation produced smaller litters, delayed ossification, and increased frequency of cleft palate (maternal toxicity shown by weight reduction); Chronic exposure of mice to low anesthetic or sub-anesthetic doses demonstrated no evidence of effects male or female fertility, reproductive loss, or early postnatal fetal wastage; A more recent study associated chronic exposure with fetal growth retardation; Chronic exposure in rabbits produced significantly reduced sperm concentrations and motility; [REPROTOX] May cause drowsiness or dizziness; [Abbott Laboratories MSDS]

Reference Link

Occupational asthma and allergy to sevoflurane and isoflurane in anaesthetic staff

Exposure Assessment
Vapor Pressure

330 mm Hg

Lethal Concentration

LC50 (rat) = 15,300 ppm/3hr

Adverse Effects
Asthma

Yes

Neurotoxin

CNS Solvent Syndrome

Reproductive Toxin

Yes

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: