Agent Name

Levodopa

Alternative Name

L-Dopa

CAS Number

59-92-7

Formula

C9-H11-N-O4

Major Category

Biological Agents

Synonyms

(-)-3-(3,4-Dihydroxyphenyl)-L-alanine; (-)-Dopa; 2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid; 3,4-Dihydroxy-L-phenylalanine; 3,4-Dihydroxyphenyl-L-alanine; 3,4-Dihydroxyphenylalanine (VAN); 3-Hydroxy-L-tyrosine; Alanine, 3-(3,4-dihydroxyphenyl)-, (-)-; Alanine, 3-(3,4-dihydroxyphenyl)-, L-; Bendopa; Biodopa; Brocadopa; Cerepap; Cerepar; Cidandopa; DA; DOPA; Deadopa; Dihydroxy-L-phenylalanine; Dopaflex; Dopaidan; Dopal; Dopal-fher; Dopalina; Dopar; Doparkine; Doparl; Dopasol; Dopaston; Dopaston SE; Dopastral; Doprin; Eldopal; Eldopar; Eldopatec; Eurodopa; Helfo DOPA; Helfo-dopa; Insulamina; L-(-)-Dopa; L-(o-Dihydroxyphenyl)alanine; L-3-(3,4-Dihydroxyphenyl)alanine; L-DOPA; L-Tyrosine, 3-hydroxy-; L-beta-(3,4-Dihydroxyphenyl)-alpha-alanine; L-beta-(3,4-Dihydroxyphenyl)alanine; L-o-Hydroxytyrosine; Larodopa; Levodopum [INN-Latin]; Levopa; Maipedopa; Pardopa; Prodopa; Ro 4-6316; Sobiodopa; Syndopa; Veldopa; beta-(3,4-Dihydroxyphenyl)-L-alanine; beta-(3,4-Dihydroxyphenyl)-alpha-L-alanine; beta-(3,4-Dihydroxyphenyl)-alpha-alanine; L-Dopa; [ChemIDplus]

Category

Amino Acids and Derivatives

Description

Colorless to white odorless solid; [Merck Index] White crystalline solid; [Sigma-Aldrich MSDS]

Sources/Uses

Natural form of dopa (precursor of the catecholamines); Used to treat Parkinson's disease; [Merck Index] "L-DOPA (L-3,4-dihydroxyphenylalanine) is a chemical that is made and used as part of the normal biology of some animals and plants. Some animals including humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines." [Wikipedia]

Comments

Teratogenic effects, early post-natal loss, and significantly delayed parturition observed in experimental animals at high doses; No evidence of adverse effects to pregnancy outcome in humans; [REPROTOX] The primary target of toxicity is the cardiovascular system, with additional effects associated with the gastrointestinal tract and nervous system; [INCHEM PIMs] A skin and strong eye irritant; Harmful by ingestion; Targets the heart; [Sigma-Aldrich MSDS] See "DL-Dihydroxyphenylalanine."

Exposure Assessment
Vapor Pressure

1.24E-10 mm Hg

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

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