Agent Name

Methyl isothiocyanate

CAS Number

556-61-6

Formula

C2-H3-N-S

Major Category

Nitrogen Compounds

Synonyms

Isothiocyanate de methyle [French]; Isothiocyanate de methyle [ISO-French]; Isothiocyanatomethane; Isothiocyanic acid, methyl ester; Isotiocianato de metilo [Spanish]; Isotiocianato di metile [Italian]; MIT; MeNCS; Methane, isothiocyanato-; Methyl isothiocyanate; Methyl mustard; Methyl mustard oil; Methyl-isothiocyanat [German]; Methylisothiocyanaat [Dutch]; Methylisothiocyanaat [Netherlands]; Methylisothiocyanat [Denmark]; Methylisothiokyanat [Czech]; Methylsenfoel [German]; Metile isotiocianato [Italian]; MITC; Morton EP-161E; Trapex; Trapex-40; Trapexide; Vorlex (Nor-Am); Vorlex 201 (Nor-Am); Vortex; WN 12; [ChemIDplus] UN2477

Category

Isothiocyanates

Description

Colorless crystals that sublime at room temperature; mp = 36 deg C; [HSDB] Pale yellow low melting solid with an acrid odor; mp = 30-34 deg C; [Alfa Aesar MSDS]

Sources/Uses

Used as an insecticide and soil fumigant; Possibly used as a chemical weapon; [HSDB] A breakdown product of the soil fumigant metam sodium; [Murray, p. 1830] The primary degradate of metam sodium and metam potassium that is responsible for their soil fumigant properties; Used as an antimicrobial on wood poles and pilings; [Reference #2]

Comments

A strong irritant, vesicant, and lacrimator; Inhalation of high concentrations can cause bronchoconstriction, lung injury, seizures, and coma; [HSDB] May cause second or third degree burns after brief skin contact. [CHRIS] Reacts with water producing carbon dioxide and methylamine; [CAMEO] A strong skin sensitizer in animal studies; [Reference #2] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; May cause skin sensitization and lachrymation; Toxic by ingestion and inhalation; [Alfa Aesar MSDS]

Reference Link

Persistent respiratory health effects after a meta...[Chest. 1994] - PubMed Result

Exposure Assessment
TIH

Yes

Vapor Pressure

3.54 mm Hg

Odor Threshold Low

1.7 ppm

Lethal Concentration

LC50 (rat) = 540 mg/m3

Explanatory Notes

Flash point = 20 deg F; [CAMEO]

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: