Agent Name

Leukotriene B4

CAS Number

71160-24-2

Formula

C20-H32-O4

Major Category

Other Uses

Synonyms

5,12-DiHETE; LTB4; 6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (S-(R*,S*-(E,E,Z,Z)))-; [ChemIDplus] (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid; Leukotriene B; [Merck Index] ((5S), 6Z, 8E, 10E, 12(R), 14Z)-5,12-Dihydroxyeicosatetraenoic acid; [Fisher Scientific MSDS]

Category

Biochemical Research

Description

Colorless liquid; [Fisher Scientific MSDS]

Sources/Uses

Leukotrienes are metabolites of arachidonic acid that are chemically related to prostaglandins and thromboxanes; They are potent bronchoconstrictors that serve an important role in immediate hypersensitivity reactions; [Merck Index] "The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)" [ChemIDplus]

Comments

An irritant; Inhalation of high concentrations may cause bronchospasm and delayed pulmonary edema; [Fisher Scientific MSDS]

Adverse Effects
Toxic Pneumonitis

Yes

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Other Information

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