Agent Name

1,3-Dioxolane

Alternative Name

Formal glycol

CAS Number

646-06-0

Formula

C3-H6-O2

Major Category

Solvents

Synonyms

1,3-Dioxacyclopentane; 1,3-Dioxolan; 1,3-Dioxole, dihydro-; Dioxolan [Czech]; Dioxolane; Ethylene glycol formal; Formal glycol; Glycol formal; Glycol methylene ether; Glycolformal; [ChemIDplus]

Category

Ethers (<C12)

Description

Colorless liquid with a mild, ethereal odor; [ACGIH]

Sources/Uses

Used as a solvent and extractant for fats, waxes, and dyes; Used in the production of phenolic-novolak resins; [HSDB] Used as a monomer to produce polyacetals and a solvent for polyesters, vinyls, and epoxys; May be used as a paint stripper; [ACGIH]

Comments

In animal studies, 1,3-dioxolane is a CNS depressant and has some effects on the liver; [HSDB] A skin irritant and severe eye irritant; Blood (leukopenia) and reproductive changes occur in animal studies. [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

20 ppm

MAK

100 ppm

Vapor Pressure

70 mm Hg

Lethal Concentration

LC50 (rat) = 20,650 mg/m3/4H

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: