Agent Name


Alternative Name


CAS Number




Major Category

Other Classes


1-Hydroxy-3-methylbenzene; 1-Methyl-3-hydroxybenzene; 3-Cresol; 3-Hydroxytoluene; 3-Methylphenol; Bacticin; Celcure Dry Mix (chemicals for wood preserving); Franklin Cresolis; Metacresol; Rover's Dog Shampoo; m-Cresylic acid; m-Hydroxytoluene; m-Kresol [German]; m-Methylphenol; m-Oxytoluene; m-Toluol; meta-Cresol; Cresol, m-; Cresol, m-isomer; Phenol, 3-methyl-; [ChemIDplus] m-Cresole; m-Cresylic; meta-Cresylic acid; Hydroxy-3-methylbenzene; 3-Methyl-1-hydroxybenzene; m-Methylphenylol; [HSDB] UN2076




Colorless or yellowish liquid with a phenolic odor; mp = 11-12 deg C; [Merck Index] Hygroscopic; [CAMEO]


Used to make synthetic resins; Also used in disinfectants, photographic developers, explosives, fungicides, and as an industrial solvent; [Merck Index] Used in combination with 2,4-xylenol (CAS# 105-67-9) as a bactericide/bacteriostat for the control of crown gall, olive knot, and burr knot in fruit, nut, and ornamental trees and vines; [EPA REDs] Used as flavoring agent or adjuvant; [FDA] Used in ore flotation, fumigation compounds, degreasing compounds, paintbrush cleaners, lubricating oils, as a wood preservative, engine and metal cleaner, and in the textile industry; [NTP] Naturally occurring in many plants, petroleum, and, coal tar, as well as emissions from the combustion of wastes, coal, wood, vehicles, and cigarettes; Used primarily as an intermediate for synthetic vitamin E, pesticides, fragrances, antioxidants, disinfectants, and preservatives; Used as a pharmaceutical bactericide and preservative; Uses for all cresol isomers include as preservatives or stabilizers in cleaning/washing agents, surface treatment products, paints, adhesives, binding agents, corrosion inhibitors, and impregnation materials; [Reference #2]


Causes burns; Inhalation may cause pulmonary edema; Exposure may cause CNS depression and hemolytic anemia; Can be absorbed through skin; [ICSC] May cause second degree burns after a few minutes contact; May cause liver and kidney injury; [CHRIS] Least toxic of the three cresol isomers; May cause skin sensitization; [HSDB] No evidence of skin sensitization in limited studies of humans and guinea pigs using p-cresol and m-/p-cresol; A survey reports hypersensitivity reactions of certain individuals to cresol (unspecified isomer); Neither isomer produced mortality or clinical signs of toxicity following exposure to saturated vapor concentrations, although inhalation of aerosols may be fatal; [Reference #2] Safe when used as a flavoring agent in food; [JECFA] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion and skin absorption; Targets the CNS, lungs, liver, kidney, and eyes; [Sigma-Aldrich MSDS] See "Cresol, all isomers."

Reference Link

ATSDR - ToxFAQs - Cresols

Exposure Assessment
Skin Designation (ACGIH)



20 mg/m3, inhalable fraction and vapor


22 mg/m3

Vapor Pressure

0.11 mm Hg

Odor Threshold Low

5 mg/m3

Lethal Concentration

LC50 (rat) > 710 mg/m3/1hr

Explanatory Notes

Odor threshold from NTP; The Guide in the Emergency Response Guidebook is for "Cresols."

Reference Link

OECD SIDS: m-/p-Cresol Category - 2003

Adverse Effects
Toxic Pneumonitis



Hepatotoxin, Secondary


Skin Burns

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

Search ChemIDplus

Related Information in HazMap

Industrial Processes with risk of exposure: