Agent Name

2,4-Dinitrophenol

CAS Number

51-28-5

Formula

C6-H4-N2-O5

Major Category

Nitrogen Compounds

Synonyms

1'alpha-2,4-Dinitrophenol; 1-Hydroxy-2,4-dinitrobenzene; 2,4-Dinitrofenol [Dutch]; 2,4-Dinitrophenol; 2,4-Dnp; AI3-01535; Aldifen; Camello mosquito coils; Chemox PE; Cobra salts; Impregna salts); DNP; Dinitrofenolo [Italian]; Dinofan; EK 102; Fenoxyl carbon N; Maroxol-50; Nitro kleenup; Nitrophen; Nitrophen (VAN); Nitrophene; Nitrophene (VAN); Osmoplastic-R; Osmotox-Plus; Phenol, alpha-dinitro-; P048; Shirakiku brand mosquito coils; Solfo Black 2B Supra; Solfo Black B; Solfo Black BB; Solfo Black G; Solfo Black SB; Tertrosulphur Black PB; Tertrosulphur PBR; X 32; alpha-Dinitrophenol; [ChemIDplus]

Category

Nitrophenols

Description

Yellow crystals with a sweet, musty odor; [CHRIS]

Sources/Uses

Used as a chemical intermediate (dyes and photographic developers), biocide in metal-working fluids, wood preservative, insecticide, polymerization inhibitor (styrene production), and veterinarian medication; [HSDB]

Comments

In the 1930s, it was used to treat obesity. Reported adverse effects included agranulocytosis, neuritis, and heart damage. Poisoning by ingestion causes uncoupling of oxidative phosphorylation with high fever, sweating, tachycardia, abdominal pain, anxiety, rapid breathing that may end in convulsions and death. Poisoning has also caused toxic hepatitis, renal failure, and cataract formation. [HSDB] May cause first degree burns after short exposure and second degee burns after longer contact; May cause cataracts after chronic exposure; [CHRIS] There is a case report of dinitrophenol causing cholestatic jaundice. [Zimmerman, p. 351] See "Dinitrophenol."

Restricted

Its use as a pesticide was cancelled. [HSDB]

Exposure Assessment
Vapor Pressure

0.00039 mm Hg

Lethal Concentration

LCLo (dog) = 300 mg/m3/30 min

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Other Poison

Uncoupler

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: