Agent Name

3-(Methylthio)propionaldehyde

Alternative Name

Methional

CAS Number

3268-49-3

Formula

C4-H8-O-S

Major Category

Other Classes

Synonyms

3-(Methylmercapto)propionaldehyde; 3-(Methylthio)propanal; 3-Methylmercaptopropyl aldehyde; Methional; Methional (natural); Methylmercaptopropionic aldehyde; Propanal, 3-(methylthio)-; Propionaldehyde, 3-(methylthio)-; beta-(Methylmercapto)propionaldehyde; beta-(Methylthio)propionaldehyde; 4-Thiapentanal; [ChemIDplus] beta-(Methylthio)propionic aldehyde; Methyl mercaptopropionaldehyde; Thia-4-pentanal; Thiapentanal; [CAMEO] MTPA; MMP; [Reference #1] 3-MTP; [RTECS] UN2785

Category

Aldehydes

Description

Colorless liquid with a pungent odor; [ICSC] Colorless to amber liquid with an extremely bad and persistent odor; [CAMEO]

Sources/Uses

Naturally present in plants and aquatic animals; Used nearly exclusively as an intermediate in chemical synthesis; Also used in small quantities as a flavoring agent; [Reference #1]

Comments

Causes skin irritation and permanent injury to eyes in studies of rabbits; Shows skin sensitizing potential in guinea pig maximization tests; Mild hemolytic effects (reduced red blood cell counts and hemoglobin levels, increased blood bilirubin levels, and signs of increased hematopoiesis in the spleen) observed in 28-day oral study of rats; No evidence of adverse effects to male or female gonads or developmental toxicity in rats; [Reference #1] A severe skin, eye, and respiratory tract irritant; May cause skin sensitization; [ICSC] May cause mild irritation; [CAMEO] Safe when used as a flavoring agent in food; [JECFA] An irritant; Harmful by ingestion and inhalation; [Alfa Aesar MSDS]

Reference Link

OECD SIDS: 3-(Methylthio) propionaldehyde - 2003

Exposure Assessment
Vapor Pressure

0.75 mm Hg

Odor Threshold Low

8.0E-5 ppm

Lethal Concentration

LC50 (rat) = 5,820 mg/m3/4hr

Explanatory Notes

Odor threshold from Reference #1

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: