Agent Name

2,2-Dimethylbutane

Alternative Name

Neohexane

CAS Number

75-83-2

Formula

C6-H14

Major Category

Solvents

Synonyms

2,2-Dimethylbutane; Butane, 2,2-dimethyl-; Neohexane; [ChemIDplus]

Category

Aliphatics, Saturated (<C12)

Description

Colorless liquid with mild gasoline-like odor; [ACGIH]

Sources/Uses

Used as solvent (vegetable oils, glues, coatings, and paints); Occur in gasoline, rubber solvent, and petroleum ether; [ACGIH] Used as a high-octane fuel and an intermediate for synthesis of organic chemicals; [Hawley]

Comments

After exposure to hexane for 10 minutes, humans experience no effect at 2000 ppm and dizziness or giddiness at 5000 ppm. Like other solvents, hexane isomers are CNS depressants and cardiac sensitizers. Isomers other than n-hexane have the same TLV-TWA. These other isomers include 2,2-dimethylbutane, 2,3-dimethylbutane, 2-methyl pentane, and 3-methyl pentane. [ACGIH] Branched hexanes are less toxic than n-hexane. Cardiac sensitization occurs in dogs inhaling neohexane at 100,000-250,000 ppm. [CHEMINFO]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

500 ppm

STEL (ACGIH)

1000 ppm

MAK

500 ppm

Vapor Pressure

319 mm Hg

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: