Agent Name

Nordihydroguaiaretic acid

CAS Number

500-38-9

Formula

C18-H22-O4

Major Category

Biological Agents

Synonyms

4,4'-(2,3-Dimethyl-1,4-butanediyl)bis-1,2-benzenediol; Nordihydroguaiaretic acid (unspecified); 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-; 2,3-Bis(3,4-dihydroxyphenylmethyl)butane; 2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane; 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol); 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol); 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol; Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-; Dihydronorguaiaretic acid; Dinorguaiaretic acid, dihydro-; NDGA; Nordihydroguairaretic acid; Norguaiaretic acid, dihydro; Norguaiaretic acid, dihydro-; Norhydroguaiaretic acid; Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-; beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane; [ChemIDplus] 4,4'-(2,3-Dimethyltetramethylene)-dipyro-catechol; 1,4-Dipyro-catechol-2,3-dimethyl-butane; beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl) butane; [JECFA]

Category

Plant Toxins

Description

Solid; [Merck Index] White odorless powder; [Alfa Aesar MSDS]

Sources/Uses

Occurs in the creosote bush; Used as an antioxidant in foods and as an antineoplastic; [Merck Index] "Nordihydroguaiaretic acid (NDGA) is a potent antioxidant compound found in the long-lived creosote bush." [Wikipedia]

Comments

This CAS# refers to the unspecified stereoisomer form; The meso- form is CAS# 27686-84-6; [Merck Index] A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS]

Restricted

Banned for use as an antioxidant in food; [EPA]

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