Agent Name

Musk ambrette

CAS Number

83-66-9

Formula

C12-H16-N2-O5

Major Category

Nitrogen Compounds

Synonyms

1-(1,1-Dimethylethyl)-2-methoxy-4-methyl-3,5-dinitrobenzene; 2,4-Dinitro-3-methyl-6-tert-butylanisole; 2,6-Dinitro-3-methoxy-1-methyl-4-tert-butylbenzene; 2,6-Dinitro-3-methoxy-4-tert-butyltoluene; 4-Methoxy-1,3-dinitro-2-methyl-5-tert-butylbenzene; 4-tert-Butyl-3-methoxy-1-methyl-2,6-dinitrobenzene; 4-tert-Butyl-3-methoxy-2,6-dinitrotoluene; 6-tert-Butyl-3-methyl-2,4-dinitroanisole; Amber musk; Ambrette musk; Artificial musk ambrette; Musk ambrette (artificial); Synthetic musk ambrette; Anisole, 6-t-butyl-3-methyl-2,4-dinitro-; Anisole, 6-tert-butyl-3-methyl-2,4-dinitro- (8CI); Benzene, 1-(1,1-dimethylethyl)-2-methoxy-4-methyl-3,5-; dinitro-; [ChemIDplus]

Category

Other Aromatics (Nitrogen)

Description

Pale yellow solid with a heavy floral-musky odor; [HSDB] Yellow solid; [Alfa Aesar MSDS]

Sources/Uses

Used as a perfume fixative; [HSDB] Used as a flavoring agent; [FDA] Used in organic synthesis; [NTP] Permitted for use as an inert ingredient in non-food pesticide products; [EPA] "Musk is a class of aromatic substances commonly used as base notes in perfumery." [Wikipedia]

Comments

A moderate skin irritant; Causes spinal cord demyelination and changes in testicular weight in 90-day dermal studies of rats; Causes muscle weakness, weight loss, brain and spinal cord demyelination in repeated-dose oral studies of rats; [RTECS] "Widely used fragrance implicated in contact photosensitivity." [ChemIDplus] Positive photopatch test results and photoallergic contact dermatitis have been reported; [HSDB] Evidence of photosensitivity, neurotoxicity, and penetration through human skin with slow excretion; No skin sensitization observed in maximization study of 25 volunteers; [ToxPlanet: EC: SCCNFP] A skin and moderate eye irritant; Toxic by ingestion; [Alfa Aesar MSDS]

Restricted

Prohibited for use as a fragrance ingredient in the EU; [ToxPlanet: EC: SCCNFP]

Exposure Assessment
Vapor Pressure

1.31E-5 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Dermatotoxin

Contact Dermatitis, Photoallergic

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: