Agent Name

m-Xylene

Alternative Name

1,3-Dimethylbenzene

CAS Number

108-38-3

Formula

C8-H10

Major Category

Solvents

Synonyms

1,3-Dimethylbenzene; 1,3-Xylene; Benzene, 1,3-dimethyl-; m-Dimethylbenzene; m-Methyltoluene; m-Xylol; Benzene, m-dimethyl-; Xylene, m-; [ChemIDplus] meta-Xylene; [ICSC] 3-Xylene; m-Methyltoluene; [HSDB] UN1307

Category

Aromatic Solvents

Description

Colorless liquid; [Merck Index] Sweet odor; [CHRIS]

Sources/Uses

Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Found in coal tar; Commercial xylene is a mixture of the o-, m-, and p- isomers with the m-isomer predominating; Used as a solvent, to make dyes, and to sterilize catgut; [Merck Index] Used as a solvent and to make polyester and alkyd resins, insecticides, aviation fuel, and dyes; [HSDB]

Comments

A skin and eye irritant; May have CNS effects; An aspiration hazard by ingestion; May have adverse effects on human reproduction or development, based on animal studies; [ICSC] May cause smarting and reddening of skin if spilled and allowed to remain on clothes; High vapor concentrations may cause mild smarting of eyes and respiratory system; May cause liver and kidney injury; [CHRIS] A local irritant; Inhalation of high concentrations may cause narcotic effects, severe coughing, and pulmonary edema; Ingestion may cause kidney and liver injury; [NTP] A skin and strong eye irritant; Harmful by inhalation and skin absorption; May cause narcosis, lung irritation, chest pain, pulmonary edema, CNS depression, blood disorders, liver and kidney injury, and reproductive disorders; [Sigma-Aldrich MSDS] See "Xylene isomers."

Exposure Assessment
BEI

Methylhippuric acids in urine = 1.5 g/g creatinine; end of shift; This BEI is for technical or commercial grades of xylenes;

Skin Designation (ACGIH)

No

TLV (ACGIH)

100 ppm

STEL (ACGIH)

150 ppm

PEL (OSHA)

100 ppm

MAK

100 ppm

IDLH (NIOSH)

900 ppm

Vapor Pressure

8.29 mm Hg

Odor Threshold Low

0.05 ppm

Lethal Concentration

LC50 (rat) = 5,984 ppm/6hr

Explanatory Notes

Odor threshold from CHRIS; The Guide in the Emergency Response Guidebook is for "Xylenes."

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: