Agent Name

Toluene-2,6-diisocyanate

Alternative Name

2,6-TDI

CAS Number

91-08-7

Formula

C9-H6-N2-O2

Major Category

Plastics & Rubber

Synonyms

1,3-Diisocyanato-2-methylbenzene; 2,6-Diisocyanato-1-methylbenzene; 2,6-Diisocyanatotoluene; 2,6-TDI; 2-Methyl-meta-phenylene isocyanate; Benzene, 1,3-diisocyanato-2-methyl-; Benzene, 2,6-diisocyanato-1-methyl-; Isocyanic acid, 2-methyl-meta-phenylene ester; 2,6-Toluene diisocyanate; Tolylene 2,6-diisocyanate; UN2078; m-Tolylene diisocyanate; meta-Tolylene diisocyanates; [ChemIDplus]

Category

Diisocyanates

Description

Colorless to pale-yellow liquid with a sharp, acrid odor; [ACGIH]

Sources/Uses

Occupational asthma reported in floor varnishers and in workers manufacturing polyurethane foams and elastomers; [Malo]

Comments

No major toxicological differences between the various isomers and commercial mixtures of TDI; TLV Basis: asthma; pulmonary function; eye irritation; [ACGIH] See "Toluene-2,4-diisocyanate."

Reference Link

Occupational asthma due to isocyanates

Exposure Assessment
BEI

Toluene diamine in urine (with hydrolysis) = 5 ug/g creatine at end of shift; [TLVs and BEIs]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.001 ppm, inhalable fraction and vapor

STEL (ACGIH)

0.005 ppm, inhalable fraction and vapor

PEL (OSHA)

Ceiling(OSHA) = 0.02 ppm

IDLH (NIOSH)

2.5 ppm

Vapor Pressure

0.02 mm Hg

Odor Threshold Low

0.05 ppm

Explanatory Notes

Odor threshold = 50 ppb with about 1/2 of volunteers detecting and identifying the material at 400 ppb; [ACGIH]

Reference Link

ATSDR Medical Management -Toluene diisocyanate

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Asthma

Yes

Toxic Pneumonitis

Yes

Fibrogenic

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: