Agent Name

N-Ethylmaleimide

CAS Number

128-53-0

Formula

C6-H7-N-O2

Major Category

Other Uses

Synonyms

Ethylmaleimide; Maleic acid N-ethylimide; Maleimide, N-ethyl-; NEM; 1H-Pyrrole-2,5-dione, 1-ethyl-; [ChemIDplus] 1-Ethyl-1H-pyrrole-2,5-dione; [Merck Index] UN2928

Category

Biochemical Research

Description

Solid; [Merck Index] Colorless crystals; [Sigma-Aldrich MSDS]

Sources/Uses

Used in cancer research; [Merck Index] "A sulfhydryl reagent that is widely used in experimental biochemical studies." [ChemIDplus]

Comments

Causes somnolence and convulsions in oral lethal-dose studies of rats; [RTECS] A strong irritant; A lachrymator when liquid; [Merck Index] Causes burns; May cause skin sensitization; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Highly toxic by ingestion; Toxic by skin absorption; [Sigma-Aldrich MSDS] Search for 128-53-0 AND (sensitizer OR sensitization OR allergic): no results; [PubMed]

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic solid, corrosive, organic, n.o.s."

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.