Agent Name

Nicotinic acid

Alternative Name

Niacin

CAS Number

59-67-6

Formula

C6-H5-N-O2

Major Category

Biological Agents

Synonyms

3-Carboxylpyridine; 3-Carboxypyridine; Acide nicotinique [INN-French]; Acido nicotinico [INN-Spanish]; Acidum nicotinicum [INN-Latin]; Akotin; Apelagrin; Bionic; Daskil; Davitamon PP; Diacin; Direktan; Efacin; Enduracin; Kyselina nikotinova [Czech]; Linic; NAH; NICO; Naotin; Niac; Niacin; Niacor; Niaspan; Niaspan Titration Starter Pack; Nicacid; Nicagin; Nicamin; Nicangin; Nico-400; Nico-Span; Nicobid; Nicocap; Nicocidin; Nicocrisina; Nicodan; Nicodelmine; Nicodon; Nicolar; Niconacid; Niconat; Niconazid; Nicorol; Nicosan 3; Nicoside; Nicosyl; Nicotamin; Nicotene; Nicotil; Nicotine acid; Nicotinipca; Nicotinsaure [German]; Nicovasan; Nicovasen; Nicyl; Nipellen; Nyclin; Pellagramin; Pellagrin; Pelonin; Peviton; Pyridine-3-carboxylic acid; Pyridine-beta-carboxylic acid; Pyridine-carboxylique-3 [French]; S115; SK-Niacin; SR 4390; Slo-niacin; Tega-Span; Tinic; Vitaplex N; Wampocap; 3-Pyridinecarboxylic acid; Pyridinecarboxylic acid, 3-; [ChemIDplus]

Category

Vitamins and Derivatives

Description

White solid; [ICSC] Colorless odorless solid; [HSDB] White powder; [Sigma-Aldrich MSDS]

Sources/Uses

Occurs naturally especially in liver, fish, yeast, and cereal grains; Used as a drug (antilipemic and vitamin); [Merck Index] Used in the chemical, agricultural, animal feed, and food industries, in cosmetics, pharmaceuticals, as a food additive, intermediate, and laboratory chemical; [IUCLID] Used as a medication, nutrient, in animal feeds, enriched flours, as a chemical intermediate, and in electroplating bathes; [HSDB] Used as a nutritional supplement; [FDA] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Comments

A mild eye irritant; [ICSC] Flushing of the skin accompanied by itching, tingling, and warmness have been observed following occupational exposure; [IUCLID] Ingestion of large amounts, e.g., by drug abusers attempting to mask drugs in the urine, can cause vomiting, abdominal pain, dizziness, and hypoglycemia followed by persistent hyperglycemia, acidosis, hypotension, and coagulopathy; Also, chronic, excessive use may cause hepatitis; [Olson, p. 445-6] May cause mild upper respiratory tract irritation; [NTP] An irritant that may cause severe eye irritation; [Sigma-Aldrich MSDS] See "Nicotinamide."

Exposure Assessment
Vapor Pressure

5.7E-6 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Processes

Industrial Processes with risk of exposure: